1-(2,6-Dimethylphenyl)-4-tosylpiperazine | 713099-74-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,6-Dimethylphenyl)-4-tosylpiperazine
• 英文别名: 1-(2,6-dimethylphenyl)-4-(4-methylphenyl)sulfonylpiperazine
• CAS: 713099-74-2
• 化学式: C₁₉H₂₄N₂O₂S
• 分子量: 344.478
• InChiKey: BQTQWVIDVRGHDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-1,3-二甲苯 、 1-(甲苯-4-磺酰基)哌嗪 在 C₃₄H₃₉N₃O₄Pd 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以86%的产率得到1-(2,6-Dimethylphenyl)-4-tosylpiperazine
  参考文献：
  名称：

  (IPr)Pd(pydc) (pydc = pyridine-2,6-dicarboxylate) – A highly active precatalyst for the sterically hindered C–N coupling reactions

  摘要：

  A new class of well-defined NHC-Pd complexes incorporating a pyridine-2-carboxylate or pyridine-2,6-dicarboxylate ligand has been synthesized. These novel complexes exhibited prominent catalytic activity in the sterically hindered C-N coupling reactions at elevated temperature, but relatively inferior reactivity at low temperature. The distinctly different reactivity of these NHC-Pd complexes was presumed to be associated with their unique structures of ancillary ligands. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2013.03.021

文献信息

• (IPr)Pd(pydc) (pydc = pyridine-2,6-dicarboxylate) – A highly active precatalyst for the sterically hindered C–N coupling reactions
  作者：Yan-Jing Li、Jin-Ling Zhang、Xiao-Jian Li、Yu Geng、Xiao-Hua Xu、Zhong Jin

  DOI：10.1016/j.jorganchem.2013.03.021

  日期：2013.8

  A new class of well-defined NHC-Pd complexes incorporating a pyridine-2-carboxylate or pyridine-2,6-dicarboxylate ligand has been synthesized. These novel complexes exhibited prominent catalytic activity in the sterically hindered C-N coupling reactions at elevated temperature, but relatively inferior reactivity at low temperature. The distinctly different reactivity of these NHC-Pd complexes was presumed to be associated with their unique structures of ancillary ligands. (C) 2013 Elsevier B.V. All rights reserved.