Nε-(2,4-dinitrophenyl)-lysine | 4262-66-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Nε-(2,4-dinitrophenyl)-lysine
• 英文别名: N^ε-(2,4-Dinitrophenyl)-lysin；2-amino-6-[(2,4-dinitrophenyl)amino]hexanoic acid；ε-DNP Lys；N⁶-(2,4-dinitro-phenyl)-DL-lysine；N⁶-(2,4-Dinitro-phenyl)-DL-lysin；2-Azaniumyl-6-(2,4-dinitroanilino)hexanoate
• CAS: 4262-66-2
• 化学式: C₁₂H₁₆N₄O₆
• 分子量: 312.282
• InChiKey: OFKKPUNNTZKBSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  167
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Nε-(2,4-dinitrophenyl)-lysine 在 哌啶 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.08h， 生成
  参考文献：
  名称：

  A Synthetic Trivalent Hapten that Aggregates anti-2,4-DNP IgG into Bicyclic Trimers

  摘要：

  This paper describes the synthesis of the trivalent hapten molecule 1, containing three 2,4-dinitrophenyl (2,4-DNP) groups, and the use of this molecule to aggregate three molecules of anti-2,4-DNP IgG into a complex with 3:2 stoichiometry (IgG(3)1(2)). The equilibrium product IgG(3)1(2) was generated in similar to 90% yield upon mixing IgG and 1; during incubation, thermodynamically unstable, high-molecular-weight aggregates (> 10(4) nm in diameter) form first and convert subsequently to IgG(3)1(2). The thermodynamics and the kinetics of the formation of aggregates were studied using size-exclusion high-performance liquid chromatography (SE-HPLC), dynamic light scattering (DLS), and analytical ultracentrifugation (AUC). An analytical model based on multiple species in equilibrium was developed and used to interpret the SE-HPLC data. The aggregate IgG(3)1(2) was more stable thermodynamically and kinetically than monomeric aggregates of this IgG with monomeric derivatives of 2,4-DNP; this stability suggests potential applications of these aggregates in biotechnology.

  DOI：

  10.1021/ja067159h
• 作为产物：
  描述：

  2,4-二硝基氟苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 碳酸氢钠 作用下， 生成 Nε-(2,4-dinitrophenyl)-lysine
  参考文献：
  名称：

  Garkuscha; Ginsburg, Zhurnal Obshchei Khimii, 1959, vol. 29, p. 1554,1556; engl. Ausg. S. 1528, 1529

  摘要：

  DOI：

文献信息

• HOCHAFFINE KOSMETISCHE MITTEL
  申请人：Wella AG

  公开号：EP1513489A2

  公开（公告）日：2005-03-16
• NANOPARTICLE CONJUGATES AND METHOD OF PRODUCTION THEREOF
  申请人：THE UNIVERSITY OF LIVERPOOL

  公开号：EP1565216A1

  公开（公告）日：2005-08-24
• PURIFICATION OF A BIVALENTLY ACTIVE ANTIBODY USING A NON-CHROMATOGRAPHIC METHOD
  申请人：President and Fellows of Harvard College

  公开号：EP2049570B1

  公开（公告）日：2016-08-10
• [DE] HOCHAFFINE KOSMETISCHE MITTEL<br/>[EN] HIGHLY AFFINE COSMETIC AGENT<br/>[FR] AGENT COSMETIQUE A AFFINITE ELEVEE
  申请人：WELLA AG

  公开号：WO2004000257A2

  公开（公告）日：2003-12-31

  Die vorliegende Erfindung betrifft ein kosmetisches Mittel, welches im wesentlichen aus einem peptidischen Linker und mindestens einem damit kovalent verbundenem kosmetischen Wirkstoff besteht.
• [EN] NANOPARTICLE CONJUGATES AND METHOD OF PRODUCTION THEREOF<br/>[FR] CONJUGATS DE NANOPARTICULES ET LEUR PROCEDE DE PRODUCTION
  申请人：UNIV LIVERPOOL

  公开号：WO2004047870A1

  公开（公告）日：2004-06-10

  The present invention provides a method for the preparation of nanoparticle conjugates comprising: protocols for synthesizing intermediate product molecules by introducing known numbers of two or more substituents into a flexible hydrophilic polymer, where one substituent is capable, optionally after deprotection, of binding to a nanoparticle, and where the other substituents are capable of participating in analytical or other applications; protocols for contacting the intermediate product molecules with nanoparticles for a period of time and under conditions effective to allow the binding of a known number of the intermediate product molecules to each nanoparticle to provide the nanoparticle conjugate.