Z-精氨酸-AMC | 88937-61-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: Z-精氨酸-AMC
• 英文名称: Cbz-Arg-Arg-AMC
• 英文别名: Z-Arg-Arg-AMC；benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
• CAS: 88937-61-5
• 化学式: C₃₀H₃₉N₉O₆
• 分子量: 621.696
• InChiKey: DLELKZFCVLJXKZ-GOTSBHOMSA-N

物化性质

• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  45
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  252
• 氢给体数：
  7
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 安全说明：
  S26,S36

文献信息

• METHODS OF TREATMENT FOR INJURED OR DISEASED JOINTS
  申请人：Mucosal Therapeutics LLC

  公开号：EP1827478A2

  公开（公告）日：2007-09-05
• EP1827478A4
  申请人：——

  公开号：EP1827478A4

  公开（公告）日：2009-08-05
• Methods of Treatment For Injured or Diseased Joints
  申请人：Jay Gregory D.

  公开号：US20080139458A1

  公开（公告）日：2008-06-12

  The invention features pharmaceutical compositions that include lubricin, a compound that inhibits an enzyme selected from the group consisting of neutrophil elastase, cathepsin B, cathepsin K, cathepsin L, cathepsin S, papain, trypsin, chymotrypsin, subtilisin, pepsin, bromelain, ficin, Protease A, Protease B, Protease D, granzyme A, granzyme B, granzyme K, pepsin, thermolysin, pronase, dipeptidyl peptidase IV, and pancreatin, and a pharmaceutically acceptable excipient. Another aspect of the invention features methods of lubricating a joint in a mammal by contacting the joint with a pharmaceutical composition of the invention. The invention also features methods of inhibiting adhesion formation between a first surface and a second surface in a mammal (e.g., between injured tissues or between injured tissue and an artificial device).
• [EN] METHODS OF TREATMENT FOR INJURED OR DISEASED JOINTS<br/>[FR] METHODES DE TRAITEMENT D'ARTICULATIONS LESEES OU MALADES
  申请人：MUCOSAL THERAPEUTICS LLC

  公开号：WO2006060473A2

  公开（公告）日：2006-06-08

  [EN] The invention features pharmaceutical compositions that include lubricin, a compound that inhibits an enzyme selected from the group consisting of neutrophil elastase, cathepsin B, cathepsin K, cathepsin L, cathepsin S, papain, trypsin, chymotrypsin, subtilisin, pepsin, bromelain, ficin, Protease A, Protease B, Protease D, granzyme A, granzyme B, granzyme K, pepsin, thermolysin, pronase, dipeptidyl peptidase IV, and pancreatin, and a pharmaceutically acceptable excipient. Another aspect of the invention features methods of lubricating a joint in a mammal by contacting the joint with a pharmaceutical composition of the invention. The invention also features methods of inhibiting adhesion formation between a first surface and a second surface in a mammal (e.g., between injured tissues or between injured tissue and an artificial device).
  [FR] L'invention concerne des compositions pharmaceutiques contenant de la lubricine, un composé qui inhibe une enzyme choisie dans le groupe constitué par l'élastase neutrophile, la cathepsine B, la cathepsine K, la cathepsine L, la cathepsine S, la papaïne, la trypsine, la chymotrypsine, la subtilisine, la pepsine, la bromelaïne, la ficine, la Protéase A, la Protéase B, la Protéase D, la granzyme A, la granzyme B, la granzyme K, la thermolysine, la pronase, la dipeptidylpeptidase IV et la pancréatine, et un excipient pharmaceutiquement acceptable. Un autre aspect de l'invention concerne des méthodes de lubrification d'une articulation de mammifère, consistant à mettre l'articulation en contact avec une composition pharmaceutique selon l'invention. L'invention concerne encore des méthodes d'inhibition de la formation d'adhérence entre une première surface et une deuxième surface chez un mammifère (entre des tissus lésés ou entre un tissu lésé et un dispositif artificiel, par exemple).