Phosphamidon is a pale yellow oily liquid with a faint odor. Used as an insecticide for citrus, cotton, and deciduous fruit and nuts. and as an acaricide. (EPA, 1998)
颜色/状态：
Pale-yellow liquid
气味：
FAINT ODOR
熔点：
-45 °C
闪点：
greater than 200 °F (NTP, 1992)
溶解度：
In water, miscible @ 25 °C
蒸汽压力：
1.65X10-5 mm Hg @ 25 °C
稳定性/保质期：
ISOMERIC MIXT STABLE IN NEUTRAL & ACID MEDIA; HALF-LIFE @ 23 °C= 13.8 DAYS @ PH 7, 2.2 DAYS @ PH 10
分解：
Hydrolyzed by alkali with t1/2 of 14 day at pH 7 and 23 °C; 2.2 day at pH 10.
Desethylphosphamidon was present in the urine of treated.../lactating goats/ both phosphamidon amide and dechlorophosphamidon amide occurred in the urine and milk...alpha-chloro-nn-diethylacetoacetamide was detected in urine and in milk.
After ip injection of cis or trans (32)P-phosphamidon in male white rats... about 60% of dose...was recovered within 24 hr after injection, most from urine. Hydrolytic products were almost entirely dimethyl phosphate, with small amount of phosphoric acid and o-demethyl phosphamidon. After foliar treatment of cotton, phosphamidon, o-demethyl phosphamidon, n-desethyl phosphamidon, hydroxyethyl phosphamidon, and dimethyl phosphate were detected externally. Internally, orthophosphate and an unknown were observed in addition to the foregoing compound. In fifth-instar tobacco budworms and bollworms, metabolism of the two isomers was similar. After injection of labeled phosphamidon.../phosphamidon, O-demethyl phosphamidon, hydroxyethyl phosphamidon, n-desethyl phosphamidon, phosphoric acid/ were observed in internal extracts /and excreta/.
Desethyl phosphamidon...alpha-chloroacetoacetic acid diethylamide, alpha-chloroacetoacetic acid ethylamide, dimethyl phosphoric acid, and unchanged phosphamidon were isolated from bean plants treated with (14)C-labeled phosphamidon. ...Metabolism of phosphamidon is unusual in that facile deethylation of the diethylamide moiety occurs with no demethylation at one of the methoxy groups. Environmental factors such as temperature and, to a lesser extent, light influence plant metabolism of phosphamidon to desethyl phosphamidon with increased rates at higher temperatures.
Rats received (32)P- and/or (14)C-labeled phosphamidon by stomach tube. .../Among metabolites found were/ vinyl hydroxyphosphamidon amide...and two compound containing only the carbon label but not further identified. Rat and rabbit liver homogenates metabolized phosphamidon... /des-n-ethyl phosphamidon and phosphamidon amide/ were found in small quantities but the hydroxy compound were not detected... .
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
癌症分类：C组可能的人类致癌物
Cancer Classification: Group C Possible Human Carcinogen
来源:Hazardous Substances Data Bank (HSDB)
毒理性
暴露途径
该物质可以通过吸入其气溶胶、通过皮肤接触以及吞食被身体吸收。
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
The main eliminative route for phosphamidon...in rats and lactating goats was via kidneys, but small amount of several metabolites were secreted into milk of lactating goats. Only traces of unchanged /phosphamidon/ were present amongst excretory products. Desethylphosphamidon was present in urine of treated animals, whereas both phosphamidon amide and dechlorophosphamidon amide occurred in urine and milk of lactating goats. ...alpha-Chloro-nn-diethylacetoacetamide was detected in urine and in milk.
After ip injection of cis or trans phosphamidon-(32)P in male white rats, excreta was collected... About 60% of dose--either isomer--was recovered within 24 hr...most from urine... .
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
磷酰胺是一种被植物迅速吸收的系统性杀虫剂...在植物中，大约两天内有50%的损失发生。
Phosphamidon is a systemic insecticide rapidly absorbed by the plant... In plants 50% loss occurs in about 2 days.
Early appearance of symptoms and steepness of acute dose-response curves (increased dosage levels produced disproportionately large increase in response) indicate that phosphamidon is rapidly and thoroughly taken up from GI tracts of birds.
Phosphamidon is absorbed by the respiratory and gastrointestinal tracts as well as by the skin. ...Experimental animal studies have shown that most of a radiolabelled doses of organophosphorus pesticides is rapidly excreted in expired air, urine, and feces.
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
申请人：BASF SE
公开号：WO2014206910A1
公开（公告）日：2014-12-31
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
