[(1,1,2,2-四氟乙氧基)甲基]环氧乙烷 | 85567-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: [(1,1,2,2-四氟乙氧基)甲基]环氧乙烷
• 中文别名: 2-(1,1,2,2-四氟乙氧基甲基)环氧乙烷
• 英文名称: 2-[(1,1,2,2-tetrafluoroethoxy)methyl]oxirane
• 英文别名: 1,1,2,2-tetrafluoroethyl glycidyl ether；2-(1,1,2,2-tetrafluoroethoxymethyl)oxirane
• CAS: 85567-21-1
• 化学式: C₅H₆F₄O₂
• mdl: MFCD00043993
• 分子量: 174.095
• InChiKey: HFNPKDDYCOMYLN-UHFFFAOYSA-N

物化性质

• 沸点：
  142-144 °C(lit.)
• 密度：
  1.38 g/mL at 25 °C(lit.)
• 闪点：
  123 °F
• 稳定性/保质期：
  避免使用强氧化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xn,Xi
• 安全说明：
  S16,S26,S33,S36/37/39
• 危险类别码：
  R20/21/22,R10,R36/37/38
• 海关编码：
  2910900090
• 危险品运输编号：
  UN 3271 3/PG 3

反应信息

• 作为反应物：
  描述：

  [(1,1,2,2-四氟乙氧基)甲基]环氧乙烷 、 4-硝基间甲苯酚 在 chiral polymer-supported Co(salen) complex 高氟叔丁醇 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Enantioselective Parallel Synthesis Using Polymer-Supported Chiral Co(salen) Complexes

  摘要：

  [GRAPHICS]The kinetic resolution of epoxides with phenols catalyzed by a polymer supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries, The corresponding 1-aryloxy-2-alcohols are obtained in high yield, purity, and enantiomeric excess. Further elaboration with diversity elements provides highly efficient access to important classes of pharmacologically active compounds.

  DOI：

  10.1021/ol990920q

文献信息

• Regioselective Conversion of Unsymmetrical Terminal Epoxides into Vicinal Chlorohydrins Using Dimethoxyboron Chloride
  作者：Chandra D. Roy

  DOI：10.1071/ch06315

  日期：——

  synthesis of chlorohydrins by chlorinative cleavage of unsymmetrical epoxides utilizing dimethoxyboron chloride is described. Except for styrene oxide, all the terminal epoxides were regioselectively cleaved following a predominantly SN2-type reaction pathway favouring the formation of primary chlorides. In the case of styrene oxide, a benzylic epoxide, (MeO)2BCl transfers the chlorine at the benzylic

  描述了使用二甲氧基氯化硼通过氯化裂解不对称环氧化物来高度区域选择性合成氯代醇。除氧化苯乙烯外，所有末端环氧化物均按照有利于形成初级氯化物的主要 SN2 型反应途径进行区域选择性裂解。在氧化苯乙烯（一种苄基环氧化物）的情况下，(MeO)2BCl 通过遵循明显的 SN1 型机制在苄基位置转移氯。
• Substituted 3-hydroxy-delta-lactones from epoxides
  申请人：Coates Geoffrey W.

  公开号：US20100145046A1

  公开（公告）日：2010-06-10

  Catalysts and methods for the carbonylation of epoxides to substituted 3-hydroxy-δ-lactones and β-lactones are disclosed.

  揭示了用于将环氧化合物羰基化为取代的3-羟基-δ-内酯和β-内酯的催化剂和方法。
• Calixarene crown ether solvent composition and use thereof for extraction of cesium from alkaline waste solutions
  申请人：Lockheed Martin Energy Research Corporation

  公开号：US06174503B1

  公开（公告）日：2001-01-16

  A solvent composition and corresponding method for extracting cesium (Cs) from aqueous neutral and alkaline solutions containing Cs and perhaps other competing metal ions is described. The method entails contacting an aqueous Cs-containing solution with a solvent consisting of a specific class of lipophilic calix[4]arene-crown ether extractants dissolved in a hydrocarbon-based diluent containing a specific class of alkyl-aromatic ether alcohols as modifiers. The cesium values are subsequently recovered from the extractant, and the solvent subsequently recycled, by contacting the Cs-containing organic solution with an aqueous stripping solution. This combined extraction and stripping method is especially useful as a process for removal of the radionuclide cesium-137 from highly alkaline waste solutions which are also very concentrated in sodium and potassium. No pre-treatment of the waste solution is necessary, and the cesium can be recovered using a safe and inexpensive stripping process using water, dilute (millimolar) acid solutions, or dilute (millimolar) salt solutions. An important application for this invention would be treatment of alkaline nuclear tank wastes. Alternatively, the invention could be applied to decontamination of acidic reprocessing wastes containing cesium-137.

  本发明描述了一种从含有铯(Cs)和其他竞争性金属离子的中性和碱性水溶液中提取铯(Cs)的溶剂组合物及相应方法。该方法涉及将含铯(Cs)的水溶液与由特定类脂溶性杯[4]芳烃冠醚萃取剂和含有特定类烷基-芳香醚醇的烃基稀释剂组成的溶剂接触。随后，从萃取剂中回收铯(Cs)价值，并通过将含Cs的有机溶液与水剥离溶液接触，随后回收溶剂，来进行铯的提取和剥离。这种联合提取和剥离方法在高度碱性废液中去除放射性核素铯-137的过程中特别有用，该废液中钠和钾的浓度也非常高。无需对废液进行预处理，可以使用安全且廉价的剥离过程使用水、稀酸溶液或稀盐溶液回收铯(Cs)。该发明的一个重要应用是处理碱性核废槽底。或者，该发明可应用于含铯-137的酸性再处理废液的去污。
• Roy, Chandra D.; Brown, Herbert C., Journal of Chemical Research, 2006, # 10, p. 639 - 641
  作者：Roy, Chandra D.、Brown, Herbert C.

  DOI：——

  日期：——
• Carbonylation of Epoxides to Substituted 3-Hydroxy-δ-Lactones
  作者：John W. Kramer、Daniel Y. Joh、Geoffrey W. Coates

  DOI：10.1021/ol702475e

  日期：2007.12.1

  Substituted 3-hydroxy-delta-lactones (3HLs) are valuable intermediates in the synthesis of pharmaceuticals and other biologically active-natural products. Herein we report the first example of the catalytic carbonylation of substituted homoglycidols to 3HLs using HCo(CO)(4). Upon optimization of the catalyst and reaction conditions, a functionally diverse set of 3HLs was prepared. Mechanistic insight was gained by observation of the carbonylation reaction using in situ IR spectroscopy, and we propose a mechanism that is consistent with previously studied epoxide carbonylation systems.