Dolastatin 16 | 192214-57-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Dolastatin 16
• 英文别名: (6S,12R,15R,18S,24S,31S)-13,24,27-trimethyl-3-(1-phenylpropan-2-yl)-12,15,28-tri(propan-2-yl)-16,25-dioxa-1,4,10,13,22,29-hexazatetracyclo[29.3.0.06,10.018,22]tetratriacontane-2,5,11,14,17,23,26,30-octone
• CAS: 192214-57-6
• 化学式: C₄₇H₇₀N₆O₁₀
• 分子量: 879.1
• InChiKey: JXOFEBNJOOEXJY-NLKHYCKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  63
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  192
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• BIO-ORTHOGONAL DRUG ACTIVATION
  申请人：KONINKLIJKE PHILIPS N.V.

  公开号：US20160106859A1

  公开（公告）日：2016-04-21

  The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.

  该发明涉及一种用于治疗学的原药激活方法，其中使用了表现出彼此生物正交反应性的非生物活性化学基团。该发明还涉及一种包含至少一种原药和至少一种激活剂的试剂盒，其中原药包含药物和第一个生物正交反应基团（触发器），而激活剂包含第二个生物正交反应基团。该发明还涉及在上述方法和试剂盒中使用的靶向治疗剂。该发明特别适用于抗体药物偶联物和双特异性及三特异性抗体衍生物。
• [EN] CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION<br/>[FR] TÉTRAZINE CLIVABLE UTILISÉE DANS L'ACTIVATION DE MÉDICAMENTS BIO-ORTHOGONAUX
  申请人：TAGWORKS PHARMACEUTICALS B V

  公开号：WO2018004338A1

  公开（公告）日：2018-01-04

  Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. The invention includes a kit for releasing a Construct CA bound to a Trigger TR, the kit comprising a tetrazine and a dienophile, wherein the Trigger is the tetrazine. The invention also includes the use of the formation of a pyridazine by reacting a tetrazine comprising a Construct CA bound thereto and a dienophile, as a chemical tool for the release, in a chemical, biological or physiological environment, of said Construct.

  本发明涉及一种引发化学裂解的进展。因此，本发明提供了将二烯作为化学可裂解基团附加到一个构造物上，并利用二烯与能够进行逆电子需求Diels-Alder反应的二烯丙烯基来诱导释放该构造物的用途。该发明包括一种用于释放与触发物TR结合的构造物CA的试剂盒，其中试剂盒包括四氮唑和二烯丙烯基，其中触发物为四氮唑。该发明还包括利用通过将含有与构造物CA结合的四氮唑和二烯丙烯基反应形成吡啶嗪的方法作为一种在化学、生物或生理环境中释放所述构造物的化学工具。
• [EN] COMPOUNDS FOR FAST AND EFFICIENT CLICK RELEASE<br/>[FR] COMPOSÉS POUR LIBÉRATION DE CHIMIE CLICK RAPIDE ET EFFICACE
  申请人：TAGWORKS PHARMACEUTICALS B V

  公开号：WO2020256546A1

  公开（公告）日：2020-12-24

  The invention disclosed herein relates to compounds, combinations, kits, and methods using same, for use in bioorthogonal release reactions. In particular, the compounds, combinations and kits of the invention can be used to achieve fast and efficient click release. Applications of the compounds, combinations, and kits of the invention include both in vitro and in vivo applications.

  本发明涉及化合物、组合物、试剂盒及其使用方法，用于生物正交释放反应。特别是，本发明的化合物、组合物和试剂盒可用于实现快速高效的点击释放。本发明的化合物、组合物和试剂盒的应用包括体外和体内应用。
• [EN] CHANNEL PROTEIN ACTIVATABLE LIPOSOMES<br/>[FR] LIPOSOMES ACTIVABLES PAR DES PROTÉINES DE CANAL
  申请人：TAGWORKS PHARMACEUTICALS B V

  公开号：WO2014081300A1

  公开（公告）日：2014-05-30

  Disclosed is a liposome, comprising a lipid bilayer enclosing a cavity, wherein the bilayer comprises a channel protein releasably linked to an eight-membered non-aromatic cyclic alkenylene group, preferably a cyclooctene group, and more preferably a trans-cyclooctene group. The liposomes are used in a kit comprising the liposome, the liposomal membrane of which comprises a channel protein linked to a Trigger, and an Activator for the Trigger, wherein the Trigger comprises the eight- membered non-aromatic cyclic alkenylene group, and the Activator comprises a diene.

  揭示了一种脂质体，包括包裹腔的脂质双层，其中双层包括与八元非芳香环烯链基（优选为环辛烯基，更优选为反式环辛烯基）可释放地连接的通道蛋白。这些脂质体用于一种套装，包括该脂质体，其脂质体膜包括连接到触发器的通道蛋白，以及用于触发器的激活剂，其中触发器包括八元非芳香环烯链基，而激活剂包括二烯。
• [EN] ACTIVATABLE LIPOSOMES<br/>[FR] LIPOSOME POUVANT ÊTRE ACTIF
  申请人：TAGWORKS PHARMACEUTICALS B V

  公开号：WO2014081299A1

  公开（公告）日：2014-05-30

  Disclosed are reactive liposome, comprising a lipid bilayer enclosing a cavity, wherein the bilayer comprises a linkage to an eight-membered non-aromatic cyclic alkenylene group, preferably a cyclooctene group, and more preferably a trans-cyclooctene group. The liposomes are use in a kit comprising the liposome linked, directly or indirectly, to a Trigger, and an Activator for the Trigger, wherein the Trigger comprises an eight-membered non-aromatic cyclic alkenylene group, and the Activator comprises a diene.

  揭示了一种反应性脂质体，包括一个脂质双层包裹的腔隙，其中该双层包括与一个含有八个成员的非芳香环烯基基团连接的连接，最好是环辛烯基团，更好是反式环辛烯基团。这些脂质体用于一种工具包，该工具包包括直接或间接地与一个触发器连接的脂质体，以及用于触发器的活化剂，其中触发器包括一个含有八个成员的非芳香环烯基基团，而活化剂包括一个二烯。