N-(4-pyrenyl)maleimide | 42189-56-0

• 物质功能分类: 化学试剂 - 有机试剂 - 三环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: N-(4-pyrenyl)maleimide
• 英文别名: N-(3-Pyrene)maleimide；1-pyren-4-ylpyrrole-2,5-dione
• CAS: 42189-56-0
• 化学式: C₂₀H₁₁NO₂
• 分子量: 297.313
• InChiKey: NPTUGEKDRBZJRE-UHFFFAOYSA-N

物化性质

• 熔点：
  235-237 °C(lit.)
• 沸点：
  438.82°C (rough estimate)
• 密度：
  1.2310 (rough estimate)
• 溶解度：
  易溶于氯仿、N,N-二甲基甲酰胺、二甲基亚砜、乙醇、甲醇
• 最大波长(λmax)：
  338nm, 325nm (MeOH)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  1
• 海关编码：
  2925190090
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338

反应信息

• 作为反应物：
  描述：

  十八硫醇 、 N-(4-pyrenyl)maleimide 以 甲醇 、 氯仿 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Vesicular aptasensor for the detection of thrombin

  摘要：

  自组装的磷脂质小泡通过硫醇-点击反应与凝血酶结合的适配体功能化。

  DOI：

  10.1039/c4cc05221h

文献信息

• Rhodium‐Catalyzed C8‐Alkenylation of Isoquinolones with Maleimides
  作者：Manisha、Devesh Chandra、Upendra Sharma

  DOI：10.1002/ejoc.202300411

  日期：2023.8.7

  Selective olefination of N-protected isoquinolones at C8-position has been achieved under rhodium catalysis. A range of maleimides were employed to obtain the olefinated products in moderate to excellent yield with excellent selectivity. Kinetic Isotope Effect (KIE) study and Hammett plot analysis were also performed to understand the reaction mechanism.

  在铑催化下，实现了C8位N-保护的异喹诺酮的选择性烯化。采用一系列马来酰亚胺以中等至优异的产率和优异的选择性获得烯化产物。还进行了动力学同位素效应（KIE）研究和哈米特图分析以了解反应机理。
• METHOD AND KIT FOR ASSESSING VIABLE CELLS
  申请人：Chemometec A/S

  公开号：EP2312943A2

  公开（公告）日：2011-04-27
• METHOD FOR ASSESSING VIABLE CELLS AND THE USE OF N-(7-DIMETHYLAMINO-4-METHYL-3-COUMARINYL)-MALEIMIDE (DACM) OR N-(9-ACRIDINYL)MALEIMIDE (NAM) FOR ASSESSMENT OF APOPTOSIS.
  申请人：Chemometec A/S

  公开号：EP2312943B1

  公开（公告）日：2019-11-06
• US9128097B2
  申请人：——

  公开号：US9128097B2

  公开（公告）日：2015-09-08
• [EN] METHOD AND KIT FOR ASSESSING VIABLE CELLS<br/>[FR] PROCÉDÉ ET TROUSSE PERMETTANT D'ÉVALUER LA VIABILITÉ CELLULAIRE
  申请人：CHEMOMETEC AS

  公开号：WO2010006615A2

  公开（公告）日：2010-01-21

  The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).