cetylmannoside | 96790-89-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: cetylmannoside
• 英文别名: (3S,4S,5S,6R)-2-hexadecoxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 96790-89-5
• 化学式: C₂₂H₄₄O₆
• 分子量: 404.588
• InChiKey: PAEMERHSTIDLSE-RPKDUVEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  cetylmannoside 在 吡啶 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 hexadecyl α-D-mannopyranoside
  参考文献：
  名称：

  Wilhelm, Falk; Chatterjee, Swapan Kumar; Rattay, Bernd, Liebigs Annalen, 1995, # 9, p. 1673 - 1680

  摘要：

  DOI：

文献信息

• [EN] BRUSH-ARM STAR POLYMERS, CONJUGATES AND PARTICLES, AND USES THEREOF<br/>[FR] POLYMÈRES EN ÉTOILE À BRAS EN BROSSE, CONJUGUÉS ET PARTICULES, ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2018106738A1

  公开（公告）日：2018-06-14

  Described herein are macromonomers, conjugates comprising the macromonomers (also referred to alternatively as "BRUSH", or "BRUSH conjugates"), and brush arm star polymer particles comprising the conjugates (also referred to as "BASPs" or "BASP particles"), each further comprising an agent (e.g., one or more therapeutic agents, diagnostic agents, or targeting moieties), as well as starting materials (e.g., crosslinkers) and other components (e.g., degradation components) thereof, as well as pharmaceutical compositions and methods of making and using the same.

  本文描述了大单体、包含这些大单体的共轭物（也称为“刷子”或“刷子共轭物”），以及包含这些共轭物的刷子臂星形聚合物微粒（也称为“BASPs”或“BASP微粒），每种都进一步包含一种药剂（例如，一个或多个治疗药剂、诊断药剂或靶向基团），以及起始材料（例如，交联剂）和其他组分（例如，降解组分），以及制备和使用这些药物组合物的方法。
• Peptides which enhance transport across tissues
  申请人：ELAN CORPORATION, Plc

  公开号：EP1281718A2

  公开（公告）日：2003-02-05

  A peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a preselected phage library is administered in vivo or in s6itu to a site in an animal, such as into the gastro-intestinal tract. At a predetermined time, the phage which is transported across a tissue barrier is harvested at a harvesting site which is separated from the site of administration by the tissue barrier to select transported phage. This transported phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the site of administration to the harvesting site. The identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue.

  一种允许或促进活性剂通过人体或动物组织运输的肽。从随机噬菌体文库或预选噬菌体文库中提取预定量的噬菌体，在体内或体外注射到动物的某个部位，如胃肠道。在预定的时间，在与给药部位通过组织屏障隔开的采集部位采集穿过组织屏障的噬菌体，以筛选出被转运的噬菌体。被转运的噬菌体在宿主体内扩增。这一循环重复预定次数（使用在最近一次循环中产生的转运噬菌体），以获得含有噬菌体的精选噬菌体文库，该噬菌体可从给药部位转运到收获部位。确定所选噬菌体文库中噬菌体编码的至少一种肽的特性，以确定允许或促进活性剂通过人体或动物组织运输的肽。
• Polyacetal polymers, conjugates, particles and uses thereof
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US11433136B2

  公开（公告）日：2022-09-06

  Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.

  本文提供了聚合物、pH 值敏感聚合物和/或连接体；包含上述聚合物和/或连接体的共轭物（可选择与一种或多种制剂和/或靶向分子偶联）；以及颗粒（例如，包含上述聚合物、连接体和/或共轭物的纳米颗粒），可用于增强一种或多种制剂在受试者体内的递送和/或功效。
• Peptides which enhance transport across tissues and methods of identifying and using the same
  申请人：——

  公开号：US20030219724A1

  公开（公告）日：2003-11-27

  A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or preselected phage library is plated unto or brought into contact with a first side, preferably the apical side, of a tissue sample or polarized tissue cell culture. At a predetermined time, the phage which is transported to a second side of the tissue opposite the first side, preferably the basolateral side, is harvested to select transported phage. This modified phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the first side to the second side. Lastly, the identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue.

  一种鉴定肽的方法，这种肽能允许或促进活性剂通过人体或动物组织的运输。将随机噬菌体文库或预选噬菌体文库中预定量的噬菌体接种到组织样本或极化组织细胞培养物的第一侧，最好是顶端侧，或使其与第一侧接触。在预定的时间，收获被转运到与第一侧相对的组织第二侧（最好是基底侧）的噬菌体，以选择转运的噬菌体。这种经过修饰的噬菌体会在宿主体内扩增。这种循环重复预定次数（使用最近一次循环中产生的转运噬菌体），以获得包含可从第一侧转运到第二侧的噬菌体的精选噬菌体文库。最后，确定所选噬菌体文库中噬菌体编码的至少一种肽的特性，以确定一种肽，这种肽可允许或促进活性剂通过人体或动物组织进行转运。
• PEPTIDES WHICH ENHANCE TRANSPORT ACROSS TISSUES AND METHODS OF IDENTIFYING AND USING THE SAME
  申请人：ELAN CORPORATION PLC

  公开号：EP0859959A1

  公开（公告）日：1998-08-26