N-[(2S,3R)-3-amino-2-hydroxy-4-(4-methylsulfonyl-phenyl)-butanoyl]-L-leucine | 125483-62-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: N-[(2S,3R)-3-amino-2-hydroxy-4-(4-methylsulfonyl-phenyl)-butanoyl]-L-leucine
• 英文别名: N-(3-Amino-2-hydroxy-4-(4-methylsulfonylphenyl)-1-oxobutyl)leucine；(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-(4-methylsulfonylphenyl)butanoyl]amino]-4-methylpentanoic acid
• CAS: 125483-62-7
• 化学式: C₁₇H₂₆N₂O₆S
• 分子量: 386.469
• InChiKey: FUAANNLYEGVRHF-ILXRZTDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0332999A2

  公开（公告）日：1989-09-20

  Compounds of formula wherein R₁, R₂, R₃, R₄, and n have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitors of enzymatic systems and they are useful in pharmaceutical field.

  式化合物 其中 R₁、R₂、R₃、R₄ 和 n 具有说明书中的含义。 式 I 的化合物是酶系统的抑制剂，可用于制药领域。
• THERAPY PROCEDURE FOR DRUG DELIVERY FOR TRIGEMINAL PAIN
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：EP2056800A2

  公开（公告）日：2009-05-13
• Therapy procedure for drug delivery for trigeminal pain
  申请人：Yeomans C. David

  公开号：US20070093420A1

  公开（公告）日：2007-04-26

  The present invention relates to methods for the treatment or prevention of trigeminal nerve-associated pain, in particular chronic, acute and procedural-related pain. The methods comprise administration of analgesic agents to the trigeminal nerve system which results in analgesia to the facial or head region.
• US5028626A
  申请人：——

  公开号：US5028626A

  公开（公告）日：1991-07-02
• US8258096B2
  申请人：——

  公开号：US8258096B2

  公开（公告）日：2012-09-04