1,2-Bis-(4-guanylphenoxy)-ethan | 121324-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2-Bis-(4-guanylphenoxy)-ethan
• 英文别名: 4,4'-(1,2-Ethanediylbis(oxy))bis-benzenecarboximidamide；4-[2-(4-carbamimidoylphenoxy)ethoxy]benzenecarboximidamide
• CAS: 121324-47-8
• 化学式: C₁₆H₁₈N₄O₂
• 分子量: 298.345
• InChiKey: PWLGDGGFMJVYHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2-Bis-(4-cyanophenoxy)-ethan 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 以86.7%的产率得到1,2-Bis-(4-guanylphenoxy)-ethan
  参考文献：
  名称：

  Discovery of decamidine as a new and potent PRMT1 inhibitor

  摘要：

  这份报告介绍了十甲胺作为蛋白质精氨酸甲基转移酶1（PRMT1）的有效抑制剂的合成和评价。

  DOI：

  10.1039/c6md00573j

文献信息

• GB507565
  申请人：——

  公开号：——

  公开（公告）日：——
• Effect of theory-based feature correlations on typicality judgments
  作者：Woo-Kyoung Ahn、Jessecae K. Marsh、Christian C. Luhmann、Kevin Lee

  DOI：10.3758/bf03195270

  日期：2002.1

  In the present study, we examine what types of feature correlations are salient in our conceptual representations. It was hypothesized that of all possible feature pairs, those that are explicitly recognized as correlated (i.e., explicit pairs) and affect typicality judgments are the ones that are more likely theory based than are those that are not explicitly recognized (i.e., implicit pairs). Real-world categories and their properties, taken from Malt and Smith (1984), were examined. We found that explicit pairs had a greater number of asymmetric dependency relations (i.e., one feature depends on the other feature, but not vice versa) and stronger dependency relations than did implicit pairs, which were statistically correlated in the environment but were not recognized as such. In addition, people more often provided specific relation labels for explicit pairs than for implicit pairs; these labels were most often causal relations. Finally, typicality judgments were more affected when explicit correlations were broken than when implicit correlations were broken. It is concluded that in natural categories, feature correlations that are explicitly represented and affect typicality judgments are the ones about which people have theories.
• 103. Amidines. Part XI. Preparation of amidines by ammonolysis of N-arylamidinium salts
  作者：P. Oxley、W. F. Short

  DOI：10.1039/jr9490000449

  日期：——
• Analogs of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia
  作者：Richard R. Tidwell、Susan Kilgore Jones、J. Dieter Geratz、Kwasi A. Ohemeng、Michael Cory、James Edwin Hall

  DOI：10.1021/jm00166a026

  日期：1990.4

  A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1,4-bis(4-amidinophenoxy)butane (butamidine, 6) and 1,3-bis(4-amidino-2-methoxyphenoxy)propane (DAMP, 16), were statistically more effective than the parent drug in treating PCP in the rat model of infection. In addition to their activity against PCP, the compounds were also evaluated for antitrypsin activity, ability to inhibit thymidylate synthetase, affinity for DNA, and toxicity. No correlation was observed between the tested molecular interactions of the diamidines and their effectiveness against PCP.
• Discovery of decamidine as a new and potent PRMT1 inhibitor
  作者：Jing Zhang、Kun Qian、Chunli Yan、Maomao He、Brenson A. Jassim、Ivaylo Ivanov、Yujun George Zheng

  DOI：10.1039/c6md00573j

  日期：——

  This report presents the synthesis and evaluation of compound decamidine as a potent inhibitor for protein arginine methyltransferase 1 (PRMT1).

  这份报告介绍了十甲胺作为蛋白质精氨酸甲基转移酶1（PRMT1）的有效抑制剂的合成和评价。