[1,2,5]噁二唑并[3,4-f]喹喔啉 | 71673-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: [1,2,5]噁二唑并[3,4-f]喹喔啉
• 中文别名: 2,4-二羟基-N-(3-羟基丙基)-3,3-二甲基-丁酰胺:(2,5-二氧代咪唑烷-4-基)脲
• 英文名称: 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide;(2,5-dioxoimidazolidin-4-yl)urea
• CAS: 71673-21-7
• 化学式: C13H25N5O7
• 分子量: 363.37
• InChiKey: DMVGDAWWCIUOJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.32
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  203
• 氢给体数：
  8
• 氢受体数：
  7

文献信息

• COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S)
  申请人：SCHMAUS Gerhard

  公开号：US20160008297A1

  公开（公告）日：2016-01-14

  The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.

  本发明主要涉及使用一种或多种特定化合物和/或其一个或多个相应盐来预防、减少或缓解瘙痒皮肤状况，和/或作为PAR-2拮抗剂。此外，本发明涉及组合物（产品或相应的配方），特别是用于局部给药，优选为化妆品或药用组合物，特别是用于预防、减少或缓解一种或多种瘙痒皮肤状况和/或产生PAR-2拮抗作用的组合物，包括或由效果量的这种化合物和/或盐以及一个或多个化妆品和/或药用可接受载体组成。
• 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone and its use in cosmetic and pharmaceutical preparations
  申请人：Schmaus Gerhard

  公开号：US20090208434A1

  公开（公告）日：2009-08-20

  The present invention concerns applications of the compound of formula 1 in cosmetic or pharmaceutical preparations.

  本发明涉及化合物1的在化妆品或药物制剂中的应用。
• COMPOSITIONS COMPRISING TRANS-TERT-BUTYL CYCLOHEXANOL AS SKIN IRRITATION-REDUCING AGENT
  申请人：Vielhaber Gabriele

  公开号：US20120121737A1

  公开（公告）日：2012-05-17

  The present invention primarily relates to the use of trans-tert-butyl cyclohexanol as skin irritation-reducing agent as well as compositions (formulations) having a skin irritation-reducing action comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent.

  本发明主要涉及将叔丁基环己醇转化为皮肤刺激减少剂的用途，以及包含叔丁基环己醇作为皮肤刺激减少剂的具有皮肤刺激减少作用的组合物（制剂）。
• Allantoin-hydrolyzed animal protein product
  申请人：CHARLES OF THE RITZ GROUP LTD.

  公开号：EP0087374A2

  公开（公告）日：1983-08-31

  A stable form of allantoin is provided which takes the form of a combined allantoin-hydrolyzed animal protein product which may be employed in the form of a hydroalcoholic solution, such as a cologne, after-shave lotion or skin toner, containing at least about 0.5% by weight allantoin which remains in solution, without crystallizing out, over extended periods of time. Methods for increasing the stability of allantoin and for forming a stable form of allantoin are also provided.

  本发明提供了一种稳定形式的尿囊素，其形式为尿囊素-水解动物蛋白的组合产品，可以水醇溶液的形式使用，例如古龙水、须后水或爽肤水，按重量计至少含有约 0.5%的尿囊素，长时间保持在溶液中而不结晶。 此外，还提供了提高尿囊素稳定性和形成尿囊素稳定形式的方法。
• COMPOUND FOR TREATING THE BUCCAL CAVITY COMPRISING A CHLORHEXIDINE SALT, A QUATERNARY AMMONIUM SALT AND A COMPLEX ALLANTOIN PANTHENOL SALT
  申请人：Laboratorios Kin, S.A.

  公开号：EP2596782A2

  公开（公告）日：2013-05-29

  Compound for treating the buccal cavity comprising a chlorhexidine salt, a quaternary ammonium salt and a complex allantoin and panthenol salt. Compound for treating the buccal cavity, which comprises the following constituents: [a] a chlorhexidine salt, such as for example chlorhexidine digluconate [b] a quaternary ammonium salt, such as for example cetylpyridine chloride, and [c] a complex allantoin and panthenol salt. It is particularly suitable for preparing toothpastes, mouthwashes, etc.

  用于治疗颊腔的化合物，由洗必泰盐、季铵盐以及尿囊素和泛醇复盐组成。用于治疗颊腔的化合物，由以下成分组成： (a) 洗必泰盐，例如洗必泰二氯葡萄糖酸盐 [b) 季铵盐，例如氯化十六烷基吡啶，以及 (c) 尿囊素和泛醇复盐。 特别适用于配制牙膏、漱口水等。