Methyl (I+/-Z)-2-amino-I+/--(methoxyimino)-4-thiazoleacetate | 65243-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl (I+/-Z)-2-amino-I+/--(methoxyimino)-4-thiazoleacetate
• 英文别名: methyl (2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetate
• CAS: 65243-09-6
• 化学式: C₇H₉N₃O₃S
• 分子量: 215.23
• InChiKey: MJAIDGPTIFCPGD-BJMVGYQFSA-N

物化性质

• 溶解度：
  可溶于二甲基亚砜、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 海关编码：
  2934100090

文献信息

• 2-THIAZOLEAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0075600A1

  公开（公告）日：1983-04-06

  2-thiazole derivatives represented by the following general formula: wherein R1 and R2 each represent a lower alkyl group containing 1 to 4 carbon atoms, and X represents a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group, a halogenoalkoxy group, a process for their preparation, and a medicinal composition containing these compounds having an immunity- controlling effect.

  其中 R1 和 R2 分别代表含有 1 至 4 个碳原子的低级烷基，X 代表低级烷基、低级烷氧基、低级烷氧羰基、卤代烷氧基。
• 4-Halogeno-2-Oxyimino-3-Oxobutyric acids
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0246603A2

  公开（公告）日：1987-11-25

  A method of producing a 4-halo-2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid ester or amide, which is a synthetic intermediate of value for the production of cephalosporins containing an aminothiazole group, characterized by reacting a 2-(substituted or unsubstituted)­hydroxyimino-3-oxobutyric acid or an ester or amide thereof with a silylating agent and reacting the resulting novel 2-­(substituted)hydroxyimino-3-silyloxy-3-butenoic acid ester or amide with a halogenating agent.

  一种生产 4-卤代-2-(取代或未取代)羟基亚氨基-3-氧代丁酸酯或酰胺的方法，它是生产含有氨基噻唑基团的头孢菌素的重要合成中间体、其特征是将 2-(取代或未取代)羟基亚氨基-3-氧代丁酸或其酯或酰胺与硅烷化剂反应，并将所得的新型 2-(取代)羟基亚氨基-3-硅氧基-3-丁烯酸酯或酰胺与卤化剂反应。
• Protected aminothiazolylacetic acid derivatives
  申请人：EISAI CHEMICAL CO., LTD.

  公开号：EP0675116A1

  公开（公告）日：1995-10-04

  Described is a protected aminothiazolylacetic acid derivative represented by the following formula (I): wherein A represents a nitrogen atom or a methine group, R¹ and R² may be the same or different and individually represent a hydrogen atom, a lower alkyl group or a substituted or unsubstituted aryl group, R³ represents a lower alkoxy group, a halogenated lower alkoxy group, a triphenylmethoxy group, a lower alkyl group or an acyloxy group, and R⁴ represents a halogen atom, a hydroxy group, a lower alkoxy group or a substituted or unsubstituted amino group; and salts thereof; as well as processes for the preparation thereof. The protected aminothaizolylacetic acid derivative according to the present invention is an useful intermediate for introducing a 2-(2-aminothiazol-4-yl)-2-alkoxyiminoacetyl group or a 2-(2-aminotiazol-4-yl)-2-alkenoyl group into a cephem skeleton.

  所描述的是一种受保护的氨基噻唑乙酸衍生物，由下式（I）表示： 其中，A 代表氮原子或甲基，R¹ 和 R² 可以相同或不同，且各自代表氢原子、低级烷基或取代或未取代的芳基，R³ 代表低级烷氧基、卤代低级烷氧基、三苯基甲氧基、低级烷基或酰氧基，R⁴ 代表卤原子、羟基、低级烷氧基或取代或未取代的氨基；及其盐类；以及其制备工艺。根据本发明的受保护氨基噻唑乙酸衍生物是一种有用的中间体，可将 2-(2-氨基噻唑-4-基)-2-烷氧基亚氨基乙酰基或 2-(2-氨基噻唑-4-基)-2-烯酰基引入头孢骨架中。
• Process for production of alkoxycarbonylaminothiazole acetic acid derivative
  申请人：TOKUYAMA CORPORATION

  公开号：EP0781769A1

  公开（公告）日：1997-07-02

  A process for producing an alkoxycarbonylaminothiazoleacetic acid derivative of formula (III): where R1 is a protected hydroxyl group and R3 is an alkoxycarbonyl group, which process comprises reacting an aminothiazoleacetic acid derivative ester with a dialkyl dicarbonate in the presence of a dialkyl carbonate to form an alkoxycarbonylaminothiazoleacetic acid derivative ester, hydrolyzing the ester with a base, separating the carbonate formed as a by-product, and neutralizing the remaining base.

  一种生产式(III)的烷氧羰基氨基噻唑乙酸衍生物的工艺： 其中 R1 是受保护的羟基，R3 是烷氧羰基，该工艺包括在碳酸二烷基酯存在下，使氨基噻唑乙酸衍生物酯与碳酸二烷基酯反应生成烷氧羰基氨基噻唑乙酸衍生物酯，用碱水解该酯，分离作为副产物生成的碳酸酯，并中和剩余的碱。
• Process for producing chloroacetylaminothiazoleacetic acid derivatives
  申请人：TOKUYAMA CORPORATION

  公开号：EP0859002B1

  公开（公告）日：2003-07-02