(S)-4-(4-bromophenyl)-3-methylbutan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-4-(4-bromophenyl)-3-methylbutan-2-one
• 英文别名: (S)-4-(4-bromophenyl)-3-methyl-3-butan-2-one；(3S)-4-(4-bromophenyl)-3-methylbutan-2-one
• 化学式: C₁₁H₁₃BrO
• 分子量: 241.128
• InChiKey: LIKJKEYGHCLTIQ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-4-(4-bromophenyl)-3-methylbut-3-en-2-one 在 Amberlite XAD-7 、 Baker’s yeast from Saccharomyces cerevisiae Type II 作用下， 以 丙酮 、 水 为溶剂， 反应 48.0h， 以83%的产率得到
  参考文献：
  名称：

  Extractive biocatalysis in the asymmetric reduction of α-alkyl, β-aryl enones by Baker’s yeast

  摘要：

  We prepared various chiral alpha-alkyl, beta-aryl ketones with good to excellent enantiomeric excess through the Baker's yeast asymmetric double-bond reduction of the corresponding alpha,beta-unsaturated substrates adsorbed onto the resin Amberlite XAD-7. This methodology was compatible with substrates bearing both electron-donating and withdrawing groups attached to the aromatic ring. Elongation of the alpha-alkyl substituent of the starting material strongly affected the reactivity and enantioselectivity of the reaction. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2017.05.009

文献信息

• Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water
  作者：Nnamdi Akporji、Vani Singhania、Jade Dussart-Gautheret、Fabrice Gallou、Bruce H. Lipshutz

  DOI：10.1039/d1cc04774d

  日期：——

  Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M. Transformations are provided that illustrate the variety of sequences now possible in 1-pot as representative examples of this environmentally attractive approach to organic synthesis.

  来自表面活性剂 TPGS-750-M 的纳米胶束的存在可以大大增强涉及烯还原酶 (ERED) 与水中化学催化的生物催化反应。提供的转换说明了现在在 1-pot 中可能出现的各种序列，作为这种对环境有吸引力的有机合成方法的代表性例子。
• ANTIMICROBIAL COMPOUNDS AND METHODS
  申请人：Curza Global LLC

  公开号：EP3911643A1

  公开（公告）日：2021-11-24
• [EN] ANTIMICROBIAL COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS ANTIMICROBIENS ET PROCÉDÉS
  申请人：CURZA GLOBAL LLC

  公开号：WO2020150372A1

  公开（公告）日：2020-07-23

  The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.
• Extractive biocatalysis in the asymmetric reduction of α-alkyl, β-aryl enones by Baker’s yeast
  作者：Rafaela M. Silva、Laura T. Okano、J. Augusto R. Rodrigues、Giuliano C. Clososki

  DOI：10.1016/j.tetasy.2017.05.009

  日期：2017.7

  We prepared various chiral alpha-alkyl, beta-aryl ketones with good to excellent enantiomeric excess through the Baker's yeast asymmetric double-bond reduction of the corresponding alpha,beta-unsaturated substrates adsorbed onto the resin Amberlite XAD-7. This methodology was compatible with substrates bearing both electron-donating and withdrawing groups attached to the aromatic ring. Elongation of the alpha-alkyl substituent of the starting material strongly affected the reactivity and enantioselectivity of the reaction. (C) 2017 Elsevier Ltd. All rights reserved.