3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)benzoic acid
• 英文别名: 3-(4-Chloro-3,5-dimethyl-pyrazol-1-yl)-benzoic acid；3-(4-chloro-3,5-dimethylpyrazol-1-yl)benzoic acid
• 化学式: C₁₂H₁₁ClN₂O₂
• 分子量: 250.685
• InChiKey: GWPKISAUZCTLPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS
  申请人：Fondazione Istituto Italiano Di Tecnologia

  公开号：US20200131157A1

  公开（公告）日：2020-04-30

  The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular to modulate CFTR protein or ABC protein activities.