(Z)-dysidazirine | 172140-90-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-dysidazirine
• 英文别名: methyl 3-[(Z)-pentadec-1-enyl]-2H-azirine-2-carboxylate
• CAS: 172140-90-8
• 化学式: C₁₉H₃₃NO₂
• 分子量: 307.477
• InChiKey: UOLCWKPNWDZCIP-NXVVXOECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-dysidazirine 在 碘 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 生成 dysidazirine 、 (S)-(+)-dysidazirine
  参考文献：
  名称：

  Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine

  摘要：

  Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.068

文献信息

• Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine
  作者：Colin K. Skepper、Doralyn S. Dalisay、Tadeusz F. Molinski

  DOI：10.1016/j.bmcl.2010.01.068

  日期：2010.3

  Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates. (C) 2010 Elsevier Ltd. All rights reserved.