Anilinopyrazole deriv. 1c

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Anilinopyrazole deriv. 1c
• 英文别名: 4-[[5-(4-bromophenyl)-1H-pyrazol-3-yl]amino]benzenesulfonamide
• 化学式: C₁₅H₁₃BrN₄O₂S
• 分子量: 393.3
• InChiKey: OMCNPZUKTXGTFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Novel compounds
  申请人：Tang Jun

  公开号：US20060142284A1

  公开（公告）日：2006-06-29

  The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to a nilinopyrazole derivatives useful as CDK2 inhibitors and use of the anilinopyrazoles in the treatment of disorders mediated by inappropriate CDK2 activity.

  本发明涉及苯胺并吡唑衍生物、制备此类苯胺并吡唑的方法以及使用此类苯胺并吡唑治疗某些疾病或病症。特别是，本发明涉及一种可用作 CDK2 抑制剂的苯胺吡唑衍生物，以及这种苯胺吡唑在治疗由 CDK2 活性不当介导的疾病中的用途。
• NOVEL COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1597234A2

  公开（公告）日：2005-11-23
• EP1597234A4
  申请人：——

  公开号：EP1597234A4

  公开（公告）日：2007-11-21
• US7507834B2
  申请人：——

  公开号：US7507834B2

  公开（公告）日：2009-03-24
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004076414A2

  公开（公告）日：2004-09-10

  The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to anilinopyrazole derivatives useful as CDK2 inhibitors and use of the anilinopyrazoles in the treatment of disorders mediated by inappropriate CDK2 activity.