1H-Indole--benzene (1/1) | 330156-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1H-Indole--benzene (1/1)
• 英文别名: benzene;1H-indole
• CAS: 330156-51-9
• 化学式: C14H13N
• 分子量: 195.26
• InChiKey: HAXSCOGBPLMKKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

文献信息

• Neuroprotective and anti-proliferative compounds
  申请人：——

  公开号：US20040102467A1

  公开（公告）日：2004-05-27

  This invention features ring-substituted pyrrolo-&bgr;-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas (I-III), which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation. 1

  这项发明涉及环取代吡咯β-咔啉衍生物和3-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮的环取代和结构衍生物，其作为神经保护和抗增殖化合物具有用途。还公开了这些化合物的制备方法，选择的生物学特性以及这些化合物在治疗人类神经系统的各种神经退行性和炎症性疾病以及治疗其他各种增殖性疾病中的用途，这些疾病的特征是失去生长或细胞分化控制，包括但不限于癌症和炎症。
• Polyfluorinated nucleoside analogs and methods of use thereof
  申请人：Kool Todd Eric

  公开号：US20060154889A1

  公开（公告）日：2006-07-13

  Nucleoside analogs comprising polyfluorinated benzene, pyrrole, pyridine, indole, isoindole, or benzoimidazole rings are shown to provide for selective base pairing with self, or other polyfluorinated analogs, in preference to native nucleic acid bases. The analogs of the invention stabilize the stacking of helices, and increase hydrophobicity when introduced into an oligonucleotide.

  本发明涉及一种核苷酸类似物，包括多氟苯、吡咯、吡啶、吲哚、异吲哚或苯并咪唑环，这些类似物被证明能够选择性地与自身或其他多氟类似物进行碱基配对，而不是与天然核酸碱基进行配对。本发明的类似物能够稳定螺旋的堆叠，并且在引入寡核苷酸时增加疏水性。
• Composition comprising at least one substituted acetylenic carbocyanin derivative, process for treating keratin fibres using it, and device therefor
  申请人：Lagrange Alain

  公开号：US20090064423A1

  公开（公告）日：2009-03-12

  The invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium, one or more cationic direct dyes comprising at least one carbon-carbon triple bond, for instance dyes of formula (I), (II) or (III) below: in which A 1 , A 2 and A 3 , independently of each other, correspond to a cationic heterocyclic group and B 1 , B 2 and B 3 , independently of each other, correspond to a particular aromatic nucleus; n may be equal to 1 or 2. The invention also relates to a process for treating keratin fibres, in particular human keratin fibres, using the abovementioned composition, and also to a multi-compartment device comprising it.

  本发明涉及一种用于染色人类角蛋白纤维的组合物，其中在化妆品可接受的介质中，包含一种或多种阳离子直接染料，其至少包含一个碳-碳三键，例如以下式(I)、(II)或(III)的染料： 其中A1、A2和A3独立地对应于一个阳离子杂环基团，B1、B2和B3独立地对应于一个特定的芳香族核；n可以等于1或2。本发明还涉及使用上述组合物处理角蛋白纤维，特别是人类角蛋白纤维的方法，以及包含它的多室装置。
• Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use
  申请人：Wood K. Thomas

  公开号：US20060051782A1

  公开（公告）日：2006-03-09

  The present invention relates to novel monooxygenase nucleic acids and polypeptides created using mutagenesis, DNA shuffling, or both, in a single iteration or multiple iterations, and methods for their creation and use. The monooxygenase enzymes of the present disclosure have particular utility as biocatalysts in industrial chemical redox reactions, such as the oxidation of aromatic hydrocarbons, for example, toluene, benzene, or nitrobenzene, into industrially desirable products. The systems and processes of the present invention are especially useful for the coupled synthesis and recovery of catechols, methylcatechols, resorcinols, methylresorcinols, hydroquinones, methylhydroquinones, hydroxybenzenes, cresols, nitrobenzenes, and nitrohydroxyquinones.

  本发明涉及使用突变、DNA重组或两者结合的方法，在单次迭代或多次迭代中创建的新型单加氧酶核酸和多肽，以及它们的创建和使用方法。本公开的单加氧酶酶在工业化学氧化还原反应中具有特定的生物催化剂实用性，例如将芳香族烃类（例如甲苯、苯或硝基苯）氧化成工业上所需的产品。本发明的系统和过程特别适用于咖啡酚、甲基咖啡酚、间苯二酚、甲基间苯二酚、对苯二酚、甲基对苯二酚、羟基苯、甲酚、硝基苯和硝基羟基苯的耦合合成和回收。
• Azepine derivaties as pharmaceutical agents
  申请人：Martin Richard

  公开号：US20070015746A1

  公开（公告）日：2007-01-18

  Compounds, compositions and methods are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the receptors.

  提供了化合物、组合物和方法，用于调节受体的活性，并用于治疗、预防或缓解与受体活性相关的一种或多种疾病或障碍的症状。