Methyl 2-(4-fluorophenyl)-7-methyl-pyrazolo[1,5-a]pyridine-3-carboxylate | 468063-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 2-(4-fluorophenyl)-7-methyl-pyrazolo[1,5-a]pyridine-3-carboxylate
• 英文别名: methyl 2-(4-fluorophenyl)-7-methylpyrazolo[1,5-a]pyridine-3-carboxylate
• CAS: 468063-19-6
• 化学式: C₁₆H₁₃FN₂O₂
• 分子量: 284.29
• InChiKey: OISYZRKEYTZZKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 2-(4-fluorophenyl)-7-methyl-pyrazolo[1,5-a]pyridine-3-carboxylate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors

  摘要：

  A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.040
• 作为产物：
  描述：

  、 3-(4-氟苯基)-2-丙炔酸甲酯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 生成 Methyl 2-(4-fluorophenyl)-7-methyl-pyrazolo[1,5-a]pyridine-3-carboxylate
  参考文献：
  名称：

  The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors

  摘要：

  A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.040

文献信息

• Use of pyrazolopyridines as therapeutic compounds
  申请人：Boyd F Leslie

  公开号：US20050107400A1

  公开（公告）日：2005-05-19

  The present invention provides methods for the treatment or prophylaxis of viral infections such as herpes viral infections.

  本发明提供了治疗或预防病毒感染，例如疱疹病毒感染的方法。
• Pyrazolopyridines, process for their preparation and use as therapeutic compounds
  申请人：Alberti John Michael

  公开号：US20060058319A1

  公开（公告）日：2006-03-16

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物：其中所有变量如本文所定义，包含这些化合物的制药组合物，制备这些化合物的过程以及它们作为制药剂的用途。
• Pyralopyridines, process for their preparation and use as therapeutic compounds
  申请人：Alberti John Michael

  公开号：US20050059677A1

  公开（公告）日：2005-03-17

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物：其中所有变量如本文所定义，包含它们的药物组合物，制备它们的方法以及它们作为药物剂量的用途。
• USE OF PYRAZOLOPYRIDINES AS THERAPEUTIC COMPOUNDS
  申请人：SmithKline Beecham Corporation

  公开号：EP1372642A1

  公开（公告）日：2004-01-02
• PYRAZOLOPYRIDINES, PROCESS FOR THEIR PREPARATION AND USE AS THERAPEUTIC COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1372643A1

  公开（公告）日：2004-01-02