methyl 3-(benzyloxy)-6-methoxypicolinate | 267416-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 3-(benzyloxy)-6-methoxypicolinate
• 英文别名: Methyl 3-benzyloxy-6-methoxypicolinate；methyl 6-methoxy-3-phenylmethoxypyridine-2-carboxylate
• CAS: 267416-44-4
• 化学式: C₁₅H₁₅NO₄
• 分子量: 273.288
• InChiKey: LGOGLSSLIBDVGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  57.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 3-(benzyloxy)-6-methoxypicolinate 在 盐酸 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以63%的产率得到3-BENZYLOXY-6-METHOXYPICOLINIC ACID
  参考文献：
  名称：

  EP1134214

  摘要：

  公开号：
• 作为产物：
  描述：

  methyl 3-benzyloxypicolinate-1-oxide 在 silver carbonate 、 乙酸酐 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 methyl 3-(benzyloxy)-6-methoxypicolinate
  参考文献：
  名称：

  [EN] MACROCYCLES AS CFTR MODULATORS
  [FR] MACROCYCLES EN TANT QUE MODULATEURS DE CFTR

  摘要：

  本发明涉及公式（I）的大环化合物，其中Ar1，Ar2，R1，R2，R3，R4和X如描述中所述，它们的制备方法，其药学上可接受的盐以及它们作为药物的用途，包括含有一个或多个公式（I）化合物的药物组合物，特别是它们作为CFTR调节剂的用途。

  公开号：

  WO2022194399A1

文献信息

• Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：US07183278B1

  公开（公告）日：2007-02-27

  Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel compounds according to the present invention include compounds represented by formula (1). The compounds represented by formula (1) have potent activity against harmful organisms, and do not have phytotoxicity against agricultural and gardening plants, as objects to which the compounds of the present invention are applied for preventive and exterminating purposes, and human beings and beasts wherein A represents a bond or an optionally substituted alkylene chain; R1 represents one or more groups, which may be the same or different, selected from the group consisting of a hydrogen atom, alkoxy, and haloalkoxy; R2 represents a hydrogen atom, benzyl, alkyl or alkanoyl, in which the groups other than the hydrogen atom may be substituted; and R3 represents a hydrogen atom, cycloalkyl, cycloalkenyl, aryl or a heterocyclic group, in which the groups other than the hydrogen atom may be substituted, excluding the case where R1 represents a hydrogen atom, A represents a bond or a methylene chain, and R3 represent phenyl or cyclohexyl, and the case where A represents an alkylene chain and R3 represents a hydrogen atom.

  本发明揭示了一种用于控制有害生物的新化合物，使用该化合物的有害生物控制剂以及制备该新化合物的方法。本发明中有用的新化合物包括由式（1）表示的化合物。式（1）表示的化合物对有害生物具有强效活性，并且不对农业和园艺植物产生植物毒性，作为本发明中应用于预防和灭除目的的对象，以及人类和动物。其中，A表示键或可选取代的烷基链；R1表示一个或多个基团，可以是相同或不同的，选自氢原子，烷氧基和卤代烷氧基；R2表示氢原子，苄基，烷基或烷酰基，其中除氢原子外的基团可以被取代；R3表示氢原子，环烷基，环烯基，芳基或杂环基，其中除氢原子外的基团可以被取代，但当R1表示氢原子，A表示键或亚甲基链，R3表示苯基或环己基时，以及当A表示烷基链，R3表示氢原子时，排除上述情况。
• PICOLINIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0507962A1

  公开（公告）日：1992-10-14

  A novel picolinic acid represented by general formula (1) and its salt, a process for producing the same, and a herbicide containing the same as the active ingredient, wherein R represents hydrogen, alkyl, etc.; R¹ and R² may be the same or different from each other and each represents cyano, phenoxy, etc.; Y represents oxygen, sulfur, etc.; and n represents 0 or 1. The derivative and its salt have an excellent herbicidal effect on a wide variety of weeds even in small doses, so that they are applicable as a herbicide to lowland and upland fields, non-crop land, and so forth.

  一种由通式（1）代表的新型吡啶甲酸及其盐，一种生产该衍生物及其盐的工艺，以及一种含有该衍生物作为活性成分的除草剂，其中R代表氢、烷基等；R¹和R²可以相同或互不相同，各自代表氰基、苯氧基等；Y代表氧、硫等；n代表0或1。该衍生物及其盐即使在小剂量下对多种杂草也有很好的除草效果，因此可作为除草剂用于低地和高地的田地、非耕地等。
• PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1134214A1

  公开（公告）日：2001-09-19

  Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel compounds according to the present invention include compounds represented by formula (1). The compounds represented by formula (1) have potent activity against harmful organisms, and do not have phytotoxicity against agricultural and gardening plants, as objects to which the compounds of the present invention are applied for preventive and exterminating purposes, and human beings and beasts. wherein A represents a bond or an optionally substituted alkylene chain; R1 represents one or more groups, which may be the same or different, selected from the group consisting of a hydrogen atom, alkoxy, and haloalkoxy; R2 represents a hydrogen atom, benzyl, alkyl or alkanoyl, in which the groups other than the hydrogen atom may be substituted; and R3 represents a hydrogen atom, cycloalkyl, cycloalkenyl, aryl or a heterocyclic group, in which the groups other than the hydrogen atom may be substituted, excluding the case where R1 represents a hydrogen atom, A represents a bond or a methylene chain, and R3 represent phenyl or cyclohexyl, and the case where A represents an alkylene chain and R3 represents a hydrogen atom.

  本发明公开了用于控制有害生物的新型化合物、使用这些化合物的有害生物控制剂以及生产这些新型化合物的工艺。根据本发明，有用的新型化合物包括由式（1）代表的化合物。式（1）代表的化合物对有害生物具有强效活性，并且对农业和园艺植物没有植物毒性，而农业和园艺植物是本发明化合物用于预防和消灭的对象，人类和野兽也是本发明化合物的对象。 其中 A 代表键或任选取代的亚烷基链；R1 代表一个或多个基团，它们可以相同或不同，选自由氢原子、烷氧基和卤代烷氧基组成的组；R2 代表氢原子、苄基、烷基或烷酰基，其中氢原子以外的基团可以被取代；以及 R3 代表氢原子、环烷基、环烯基、芳基或杂环基，其中氢原子以外的基团可被取代，但不包括 R1 代表氢原子、A 代表键或亚甲基链、R3 代表苯基或环己基的情况，以及 A 代表亚烷基链、R3 代表氢原子的情况。
• Fungicidal heterocyclic aromatic amides, their compositions and methods of use
  申请人：Dow AgroSciences LLC

  公开号：EP1493733A2

  公开（公告）日：2005-01-05

  The present invention relates to the field of fungicidal compositions and methods. More particularly, the present invention concerns novel fungicidal heterocyclic aromatic amides of following formula I: wherein: represents a 5 membered heterocyclic aromatic ring, and methods involving application of fungicidally effective amounts of such compounds to the locus of a plant pathogen. The present invention also concerns methods useful in the preparation of heterocyclic aromatic amides and their fungicidal compositions.

  本发明涉及杀菌组合物和方法领域。更具体地说，本发明涉及下式 I 的新型杀菌杂环芳香酰胺： 其中 代表 5 个成员的杂环芳香环，以及将杀真菌有效量的此类化合物施用到植物病原体位点的方法。本发明还涉及用于制备杂环芳香酰胺及其杀菌组合物的方法。
• Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
  申请人：Dow AgroSciences, LLC

  公开号：EP1516874B1

  公开（公告）日：2015-08-19