Imidazo-pyrimidine derivatives as ligands for gaba receptors
申请人:——
公开号:US20040138236A1
公开(公告)日:2004-07-15
A class of 3-phenylimidazo[1,2-c]pyrimidine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, are selective ligands for GABA
A
receptors, in particular having good affinity for the &agr;
2
and/or &agr;
3
subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.
[EN] IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-PYRIMIDINE UTILISES COMME LIGANDS POUR RECEPTEURS GABA
申请人:MERCK SHARP & DOHME
公开号:WO2002038569A1
公开(公告)日:2002-05-16
A class of 3-phenylimidazo[1,2-c]pyrimidine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, are selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.
Imidazo[1,2-C]pyrimidine derivatives as ligands for gaba receptors
申请人:Hallett David James
公开号:US06914065B2
公开(公告)日:2005-07-05
A class of 3-phenylimidazo[1,2-c]pyrimidine derivatives, of the formula I:
(wherein R
1
, X, Y, and Z are defined herein) are selective ligands for GABA-A receptors and are useful in the treatment or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.