N-Cyclohexyl-2-(((5-methyl-2-(p-tolyl)oxazol-4-yl)methyl)sulfinyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-Cyclohexyl-2-(((5-methyl-2-(p-tolyl)oxazol-4-yl)methyl)sulfinyl)acetamide
• 英文别名: N-cyclohexyl-2-[[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methylsulfinyl]acetamide
• 化学式: C₂₀H₂₆N₂O₃S
• 分子量: 374.5
• InChiKey: GIIOAEXDWXJUKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  91.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF
  申请人：DASGUPTA Ramanuj

  公开号：US20120264744A1

  公开（公告）日：2012-10-18

  A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
• US8252823B2
  申请人：——

  公开号：US8252823B2

  公开（公告）日：2012-08-28
• US9173871B2
  申请人：——

  公开号：US9173871B2

  公开（公告）日：2015-11-03
• US9433611B2
  申请人：——

  公开号：US9433611B2

  公开（公告）日：2016-09-06