2-(3-Methylbutan-2-yl)oxirane | 88416-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 2-(3-Methylbutan-2-yl)oxirane
• CAS: 88416-20-0
• 化学式: C₇H₁₄O
• 分子量: 114.19
• InChiKey: AFQRTZMHQZXZIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BRUTON'S TYROSINE KINASE<br/>[FR] DÉRIVÉS DE PYRAZOLOPYRIMIDINE UTILES COMME INHIBITEURS DE LA TYROSINE KINASE DE BRUTON
  申请人：REDX PHARMA PLC

  公开号：WO2015189620A1

  公开（公告）日：2015-12-17

  This invention relates to compounds of formula (I). The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK). The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

  这项发明涉及式(I)的化合物。该发明的化合物是酪氨酸激酶抑制剂。具体来说，该发明的化合物可用作布鲁顿酪氨酸激酶（BTK）的抑制剂。该发明还考虑了利用这些化合物治疗可通过抑制布鲁顿酪氨酸激酶治疗的疾病，例如癌症、淋巴瘤、白血病和免疫性疾病。
• Process for producing 1,3-dialkyl-2-imidazolidinone compound
  申请人：——

  公开号：US20030009035A1

  公开（公告）日：2003-01-09

  There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50 ° C. or higher to give 1,3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A), a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1,3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide. The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.

  提供了一种制备1,3-二烷基-2-咪唑烷酮的方法，该方法使用乙烯氧化物作为第一组分，至少使用以下之一：（A）二氧化碳和一种单烷基胺；（B）单烷基胺的二氧化碳化合物；和（C）1,3-二烷基脲，通过加热至50°C或更高温度来使第一和第二组分反应，得到1,3-二烷基-2-咪唑烷酮，其特点是：单烷基胺的摩尔进料量包括在组分（A）中的单烷基胺的摩尔进料量，单烷基胺的二氧化碳化合物中的单烷基胺部分的摩尔进料量，组分（B），以及1,3-二烷基脲的摩尔进料量的两倍，组分（C），至少是乙烯氧化物的摩尔进料量的三倍。这种发明的制备过程使用工业上易得的乙烯氧化物作为起始物质，并且可以在工业规模上以更高的产率进行适当的操作。
• PROCESS FOR PRODUCING 1,3-DIALKYL-2-IMIDAZOLIDINONE COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1279667A1

  公开（公告）日：2003-01-29

  There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50 °C or higher to give 1, 3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A) , a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1, 3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide. The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.

  本发明提供了一种制备 1，3-二烷基-2-咪唑烷酮的工艺，该工艺以环氧亚 烷为第一组分，使用 (A) 二氧化碳和单烷基胺；(B) 单烷基胺的二氧化碳化合物；和 (C) 1，3-二烷基脲中的至少一种；和 (C) 1，3-二烷基脲，通过在 50℃或更高温度下加热使第一和第二组分反应，得到 1，3-二烷基-2-咪唑烷酮，其特征在于，组分 (A) 中包含的单烷基胺的摩尔进料总量 、单烷基胺二氧化碳化合物的单烷基胺部分的摩尔进料量，组分(B)，以及 1，3-二烷基脲的摩尔进料量的双倍，组分(C)，至少是环氧亚烷基摩尔进料量的三倍。 本发明的制备工艺使用工业上容易获得的环氧亚烷烃作为起始原料，可以适当地在工业规模上以更高的产率进行。
• US4433079A
  申请人：——

  公开号：US4433079A

  公开（公告）日：1984-02-21
• US6861534B2
  申请人：——

  公开号：US6861534B2

  公开（公告）日：2005-03-01