(2-Ethylpiperidin-1-yl)(3-methyl-6-phenylimidazo[2,1-b]thiazol-2-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2-Ethylpiperidin-1-yl)(3-methyl-6-phenylimidazo[2,1-b]thiazol-2-yl)methanone
• 英文别名: (2-ethylpiperidin-1-yl)-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)methanone
• 化学式: C₂₀H₂₃N₃OS
• 分子量: 353.5
• InChiKey: WYYROWUPMHQCPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  65.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：US20150238475A1

  公开（公告）日：2015-08-27

  Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
• US8568756B2
  申请人：——

  公开号：US8568756B2

  公开（公告）日：2013-10-29
• US9045476B2
  申请人：——

  公开号：US9045476B2

  公开（公告）日：2015-06-02
• US9415040B2
  申请人：——

  公开号：US9415040B2

  公开（公告）日：2016-08-16