5-(4'-fluoro-[1,1'-biphenyl]-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole | 928135-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4'-fluoro-[1,1'-biphenyl]-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole
• 英文别名: (5R)-5-[2-(4-fluorophenyl)phenyl]-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole
• CAS: 928135-13-1
• 化学式: C₁₈H₁₅FN₂
• 分子量: 278.329
• InChiKey: MJYUFUVTQSRGKQ-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1-三苯甲游基-1H-咪唑-4-基)乙酸 在 咪唑 、 盐酸 、 氯化亚砜 、 硼烷四氢呋喃络合物 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 乙腈 为溶剂， 反应 2.5h， 生成 5-(4'-fluoro-[1,1'-biphenyl]-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole 、 5-(4'-fluoro-[1,1'-biphenyl]-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole
  参考文献：
  名称：

  Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

  摘要：

  Aldosterone is a key signaling component of the renin-angiotensin-aldosterone system and as such has been shown to contribute to cardiovascular pathology such as hypertension and heart failure. Aldosterone synthase (CYP11B2) is responsible for the final three steps of aldosterone synthesis and thus is a viable therapeutic target A series of imidazole derived inhibitors, including clinical candidate 7n, have been identified through design and structure-activity relationship studies both in vitro and in vivo. Compound 7n was also found to be a potent inhibitor of 11 beta-hydroxylase (CYP11B1), which is responsible for cortisol production. Inhibition of CYP11B1 is being evaluated in the clinic for potential treatment of hypercortisol diseases such as Cushing's syndrome.

  DOI：

  10.1021/ml400324c

文献信息

• Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors
  作者：Erik L. Meredith、Gary Ksander、Lauren G. Monovich、Julien P. N. Papillon、Qian Liu、Karl Miranda、Patrick Morris、Chang Rao、Robin Burgis、Michael Capparelli、Qi-Ying Hu、Alok Singh、Dean F. Rigel、Arco Y. Jeng、Michael Beil、Fumin Fu、Chii-Whei Hu、Daniel LaSala

  DOI：10.1021/ml400324c

  日期：2013.12.12

  Aldosterone is a key signaling component of the renin-angiotensin-aldosterone system and as such has been shown to contribute to cardiovascular pathology such as hypertension and heart failure. Aldosterone synthase (CYP11B2) is responsible for the final three steps of aldosterone synthesis and thus is a viable therapeutic target A series of imidazole derived inhibitors, including clinical candidate 7n, have been identified through design and structure-activity relationship studies both in vitro and in vivo. Compound 7n was also found to be a potent inhibitor of 11 beta-hydroxylase (CYP11B1), which is responsible for cortisol production. Inhibition of CYP11B1 is being evaluated in the clinic for potential treatment of hypercortisol diseases such as Cushing's syndrome.