N-[(Morpholin-4-yl)methyl]prop-2-enamide | 16673-08-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-[(Morpholin-4-yl)methyl]prop-2-enamide
• 英文别名: N-(morpholin-4-ylmethyl)prop-2-enamide
• CAS: 16673-08-8
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.21
• InChiKey: YYMRAHJYANNJQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-羟甲基丙烯酰胺 、 对苯二酚 、 吗啉 在 乙酸乙酯 作用下， 以 水 为溶剂， 50.0~160.0 ℃ 、177.32 Pa 条件下， 反应 1.0h， 以to obtain 34.5 g of fraction of 140°-160°C/0.01 mmHg (45.7%)的产率得到N-[(Morpholin-4-yl)methyl]prop-2-enamide
  参考文献：
  名称：

  Photographic silver halide emulsion comprising an amphoteric copolymer

  摘要：

  含有新型两性共聚物的照相乳剂，包括：A. 0.5至30摩尔％的阳离子位点含有公式（I）的重复单元，其中R1表示氢原子或甲基基团，n为1、2、3或4；B. 0.5至30摩尔％的阴离子位点含有公式（II）的重复单元，其中R2表示氢原子或甲基基团，X表示##SPC1## --COOM、--SO3M或--COO(CH2)mSO3M，其中M为阳离子，m为3或4；C. 公式（III）的重复单元的平衡，其中R3表示氢原子或甲基基团，R4和R5各表示氢原子或较低的烷基基团或其取代基。这种新型两性共聚物可以部分或完全替代照相乳剂中的明胶，具有优异的照相效果。

  公开号：

  US03957492A1

文献信息

• [EN] COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS<br/>[FR] COMPOSÉS POUR INHIBER LA PROLIFÉRATION CELLULAIRE DANS LES CANCERS INDUITS PAR L'EGFR
  申请人：ARIAD PHARMA INC

  公开号：WO2013169401A1

  公开（公告）日：2013-11-14

  The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula (I), wherein the variables are as defined herein.

  这项发明涉及化合物、药物组合物和治疗EGFR驱动的Formula (I)癌症患者的方法，其中变量如本文所定义。
• COSMETIC COMPOSITION COMPRISING AT LEAST ONE CATIONIC COPOLYMER AND AT LEAST ONE ANIONIC ASSOCIATIVE POLYMER AND COSMETIC TREATMENT PROCESSES USING SAID COMPOSITION
  申请人：BIGANSKA Olga

  公开号：US20090074692A1

  公开（公告）日：2009-03-19

  The disclosure relates to novel cosmetic compositions comprising, in a cosmetically acceptable medium: (i) at least one cationic polymer which are produced by polymerization of a mixture of monomers comprising: a) at least one vinyl monomer substituted with at least one amino group, b) at least one hydrophobic nonionic vinyl monomer, c) at least one associative vinyl monomer, and e) at least one hydroxylated nonionic vinyl monomer, and (ii) at least one anionic associative polymers.

  该披露涉及新型化妆品组合物，包括在适合用于化妆的介质中的：(i) 至少一种阳离子聚合物，其由包括：a) 至少一种含有至少一个氨基团的乙烯单体，b) 至少一种疏水非离子乙烯单体，c) 至少一种关联性乙烯单体，和e) 至少一种羟基化非离子乙烯单体的单体混合物聚合而成，以及(ii) 至少一种阴离子关联性聚合物。
• COSMETIC COMPOSITION COMPRISING A CATIONIC COPOLYMER AND A STARCH AND COSMETIC TREATMENT PROCESS THEREOF
  申请人：BIGANSKA Olga

  公开号：US20090074696A1

  公开（公告）日：2009-03-19

  The disclosure relates to novel cosmetic compositions comprising, in a cosmetically acceptable medium: (i) at least one cationic polymer which is obtained by polymerization of a mixture of monomers comprising: a) at least one vinyl monomer substituted with at least one amino group, b) at least one hydrophobic nonionic vinyl monomer, chosen from those of formulae (I) and (II): CH 2 ═C(X)Z,  (I) CH 2 ═CH—OC(O)R;  (II) wherein X, Z, and R are defined in the present specification; c) at least one associative vinyl monomer, and d) at least one hydroxylated nonionic vinyl monomer; and (ii) at least one starch. These compositions may have a texture which does not change over time and which may allow a better distribution, better lathering properties and also better cosmetic properties.

  该披露涉及一种新型化妆品组合物，包括在化妆品可接受的介质中：(i) 至少一种通过聚合包含以下单体混合物获得的阳离子聚合物：a) 至少一种含有至少一个氨基团的乙烯单体，b) 至少一种疏水非离子乙烯单体，选择自以下式(I)和(II)的那些：CH2═C(X)Z，(I)CH2═CH—OC(O)R；(II)，其中X、Z和R在本说明书中有定义；c) 至少一种缔合性乙烯单体，和d) 至少一种羟基化非离子乙烯单体；以及(ii) 至少一种淀粉。这些组合物可能具有随时间不变的质地，可能允许更好的分布、更好的起泡性能和更好的化妆性能。
• Multi-purpose polymers, methods and compositions
  申请人：——

  公开号：US20040241130A1

  公开（公告）日：2004-12-02

  Disclosed are multi-purpose polymers that are the polymerization product of a monomer mixture comprising at least one amino-substituted vinyl monomer; at least one nonionic vinyl monomer; at least one associative vinyl monomer; at least one semihydrophobic vinyl surfactant monomer; and, optionally, comprising one or more hydroxy-substituted nonionic vinyl monomer, crosslinking monomer, chain transfer agent or polymeric stabilizer. These vinyl addition polymers have a combination of substituents, including amino substituents that provide cationic properties at low pH, hydrophobic substituents, hydrophobically modified polyoxyalkylene substituents, and hydrophilic polyoxyalkylene substituents. The polymers provide surprisingly beneficial Theological properties in acidic aqueous compositions, and are compatible with cationic materials. Additionally, this invention relates to the incorporation of a basic material after the addition of an acidic material to reduce the pH of the composition without negatively impacting the viscosity of the composition. The multi-purpose polymers are useful in a variety of products for personal care, health care, household care, institutional and industrial care, and industrial applications.

  本发明涉及多用途聚合物，其为单体混合物的聚合物化产物，包括至少一种氨基取代的乙烯单体；至少一种非离子乙烯单体；至少一种联合乙烯单体；至少一种半亲水性乙烯表面活性剂单体；以及可选地包括一种或多种羟基取代的非离子乙烯单体、交联剂、链转移剂或聚合稳定剂。这些乙烯加成聚合物具有一些取代基的组合，包括在低pH下提供阳离子性质的氨基取代基、疏水取代基、疏水改性的聚氧烷基取代基和亲水性的聚氧烷基取代基。这些聚合物在酸性水性组合物中提供了出乎意料的有益流变特性，并且与阳离子材料兼容。此外，本发明还涉及在添加酸性物质后加入碱性物质以降低组合物的pH值，而不会对组合物的粘度产生负面影响。这些多用途聚合物在个人护理、健康护理、家庭护理、机构和工业护理以及工业应用的各种产品中非常有用。
• Multi-Purpose Polymers, Methods and Compositions
  申请人：Tamareselvy Krishnan

  公开号：US20080233069A1

  公开（公告）日：2008-09-25

  Disclosed are multi-purpose polymers that are the polymerization product of a monomer mixture comprising at least one amino-substituted vinyl monomer; at least one nonionic vinyl monomer; at least one associative vinyl monomer; at least one semihydrophobic vinyl surfactant monomer; and, optionally, comprising one or more hydroxy-substituted nonionic vinyl monomer, crosslinking monomer, chain transfer agent or polymeric stabilizer. These vinyl addition polymers have a combination of substituents, including amino substituents that provide cationic properties at low pH, hydrophobic substituents, hydrophobically modified polyoxyalkylene substituents, and hydrophilic polyoxyalkylene substituents. The polymers provide surprisingly beneficial rheological properties in acidic aqueous compositions, and are compatible with cationic materials. The multi-purpose polymers are useful in a variety of products for personal care, health care, household care, institutional and industrial care, and industrial applications.

  本发明涉及多用途聚合物，其为单体混合物的聚合物化产物，所述单体混合物包括至少一种氨基取代乙烯单体；至少一种非离子乙烯单体；至少一种缔合乙烯单体；至少一种半亲水性乙烯表面活性剂单体；以及可选地，包括一种或多种羟基取代的非离子乙烯单体、交联单体、链转移剂或聚合稳定剂。这些乙烯加成聚合物具有一系列取代基，包括在低pH值下提供阳离子性质的氨基取代基，疏水取代基，疏水修饰的聚氧烷基取代基和亲水性聚氧烷基取代基。这些聚合物在酸性水溶性组合物中提供出人意料的有益流变特性，并且与阳离子材料兼容。这些多用途聚合物在个人护理、健康护理、家庭护理、机构和工业护理以及工业应用的各种产品中非常有用。