tert-Butyl (4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-yl)carbamate | 365428-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-Butyl (4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-yl)carbamate
• 英文别名: tert-butyl N-[4-[4-(3-methylphenyl)-2-(4-methylsulfanylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]carbamate
• CAS: 365428-44-0
• 化学式: C₂₇H₂₇N₃O₂S₂
• 分子量: 489.7
• InChiKey: LBKUJJSFQFOLCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Substituted 1,3-thiazole compounds, their production and use
  申请人：——

  公开号：US20040053973A1

  公开（公告）日：2004-03-18

  (1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

  (1) 一种1,3-噻唑化合物，其5位被取代为含有一个取代基的4-吡啶基团，该取代基不包括芳香基，或者(2) 一种1,3-噻唑化合物，其5位被取代为一个吡啶基团，该吡啶基团的氮原子邻近位置有一个取代基，该取代基不包括芳香基，具有出色的p38 MAP激酶抑制活性。
• MEDICINAL COMPOSITIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1402900A1

  公开（公告）日：2004-03-31

  The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

  本发明涉及一种用于预防或治疗疼痛的药剂，一种用于抑制破骨细胞活化的药剂，以及一种包含p38 MAP激酶抑制剂和/或TNF-α产生抑制剂的破骨细胞形成抑制剂。
• Biaryl compound and use thereof
  申请人：Cho Nobuo

  公开号：US20050096359A1

  公开（公告）日：2005-05-05

  The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I): wherein ring A and ring B are optionally further substituted 6-membered aromatic rings; X is —CONR 4 —, —SO 2 NR 4 —, —CH 2 NR 4 — (R 4 is a hydrogen atom, an optionally substituted hydrocarbon group, etc.), etc.; Y is a spacer having 1 to 12 atoms, etc.; Z is —CONR 6 —, —CO— (R 6 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group), etc.; R 1 is an optionally substituted amino group, etc.; R 2 is an optionally substituted hydrocarbon group, etc.; R 3 is an optionally substituted hydrocarbon group, etc.; and R 5 is an optionally substituted hydrocarbon group, etc.; or a salt thereof.

  本发明提供了一种具有黑色素细胞激素受体激动剂或拮抗剂活性的化合物，该化合物是一种新的双芳基化合物，其表示式为（I）：其中环A和环B是可选进一步取代的6元芳香环；X是—CONR4—，—SO2NR4—，—CH2NR4—（其中R4是氢原子、可选取代的碳氢基团等）等；Y是具有1至12个原子的间隔物等；Z是—CONR6—，—CO—（其中R6是氢原子、可选取代的碳氢基团或可选取代的杂环基团）等；R1是可选取代的氨基等；R2是可选取代的碳氢基团等；R3是可选取代的碳氢基团等；R5是可选取代的碳氢基团等；或其盐。
• BIARYL COMPOUND AND USE THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1466904A1

  公开（公告）日：2004-10-13

  The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I) :    wherein ring A and ring B are optionally further substituted 6-membered aromatic rings; X is -CONR4-, -SO2NR4-, -CH2NR4- (R4is a hydrogen atom, an optionally substituted hydrocarbon group, etc.), etc.; Y is a spacer having 1 to 12 atoms, etc.; Z is -CONR6-, -CO- (R6 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group), etc.; R1 is an optionally substituted amino group, etc.; R2 is an optionally substituted hydrocarbon group, etc.; R3 is an optionally substituted hydrocarbon group, etc.; and R5 is an optionally substituted hydrocarbon group, etc.; or a salt thereof.

  本发明提供了一种具有黑色素皮质素受体激动剂活性或拮抗剂活性的化合物，它是由式(I)表示的新型双芳基化合物： 其中环 A 和环 B 是任选进一步取代的 6 元芳香环；X 是-CONR4-、-SO2NR4-、-CH2NR4-（R4 是氢原子、任选取代的烃基等）等；Y 是具有 1 至 12 个原子的间隔物等。Z 是-CONR6-、-CO-（R6 是氢原子、任选取代的烃基或任选取代的杂环基）等；R1 是任选取代的氨基等；R2 是任选取代的烃基等；R3 是任选取代的烃基等；R5 是任选取代的烃基等；或其盐。
• [EN] SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE<br/>[FR] COMPOSES DE 1,3-THIAZOLE SUBSTITUES, PRODUCTION ET UTILISATION DESDITS COMPOSES
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2001074811A2

  公开（公告）日：2001-10-11

  (1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

  (1) 一种1,3-噻唑化合物，其中5位被一个带有不包括芳香族的取代基的4-吡啶基取代，或者(2)一种1,3-噻唑化合物，其中5位被一个在吡啶基的氮原子邻近位置带有不包括芳香族的取代基的吡啶基取代。这类化合物展现出优异的p38丝裂原活化蛋白激酶抑制活性。