4-[3-(3-methylphenyl)-5-piperidin-4-yl-1H-pyrazol-4-yl]pyridine | 1065618-35-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-(3-methylphenyl)-5-piperidin-4-yl-1H-pyrazol-4-yl]pyridine
• CAS: 1065618-35-0；1072912-19-6
• 化学式: C₂₀H₂₂N₄
• 分子量: 318.421
• InChiKey: GPSYTWDNKCLQBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 4-[3-(3-methylphenyl)-5-piperidin-4-yl-1H-pyrazol-4-yl]pyridine 在 甲酸 作用下， 生成 4-(5-(1-methylpiperidin-4-yl)-3-m-tolyl-1H-pyrazol-4-yl)pyridine
  参考文献：
  名称：

  Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

  摘要：

  Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38 alpha kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position leading to analogs that were potent in human whole blood based cell assay as well as in a number of animal efficacy models for rheumatoid arthritis. Ultimately, we identified a clinical candidate from this substrate; SD-0006. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.047
• 作为产物：
  描述：

  tert-butyl 4-(4-(pyridin-4-yl)-3-(m-tolyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 4-[3-(3-methylphenyl)-5-piperidin-4-yl-1H-pyrazol-4-yl]pyridine
  参考文献：
  名称：

  Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

  摘要：

  Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38 alpha kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position leading to analogs that were potent in human whole blood based cell assay as well as in a number of animal efficacy models for rheumatoid arthritis. Ultimately, we identified a clinical candidate from this substrate; SD-0006. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.047

文献信息

• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase
  作者：John K. Walker、Shaun R. Selness、Rajesh V. Devraj、Michael E. Hepperle、Win Naing、Huey Shieh、Ravi Kurambail、Syaulan Yang、Daniel L. Flynn、Alan G. Benson、Dean M. Messing、Tom Dice、Tina Kim、R.J. Lindmark、Joseph B. Monahan、Joseph Portanova

  DOI：10.1016/j.bmcl.2010.02.047

  日期：2010.4

  Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38 alpha kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position leading to analogs that were potent in human whole blood based cell assay as well as in a number of animal efficacy models for rheumatoid arthritis. Ultimately, we identified a clinical candidate from this substrate; SD-0006. (C) 2010 Elsevier Ltd. All rights reserved.