1-(4-(1H-tetrazol-5-yl)phenyl)-3-phenylurea | 651769-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-(1H-tetrazol-5-yl)phenyl)-3-phenylurea
• 英文别名: 1-Phenyl-3-[4-(1h-Tetrazol-5-Yl)phenyl]urea；1-phenyl-3-[4-(2H-tetrazol-5-yl)phenyl]urea
• CAS: 651769-74-3
• 化学式: C₁₄H₁₂N₆O
• 分子量: 280.289
• InChiKey: KTIWLNFSBOCUHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Human helicase DDX3 inhibitors as therapeutic agents
  申请人：AZIENDA OSPEDALIERA UNIVERSITARIA SENESE

  公开号：US10941121B2

  公开（公告）日：2021-03-09

  The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.

  本发明是指具有式 I 和 II 的 RNA 螺旋酶 DDX3 抑制活性的化合物及其治疗用途，特别是用于治疗病毒性疾病。
• Use of DDX3 inhibitors as antiproliferative agents
  申请人：AZIENDA OSPEDALIERA UNIVERSITARIA SENESE

  公开号：US11000512B2

  公开（公告）日：2021-05-11

  The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents. (I) or (II).

  本发明涉及具有 DDX3 抑制活性的式 I 或式 II 化合物、相关药物组合物及其作为抗过增殖剂的用途。(I)或(II)。
• USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS
  申请人：AZIENDA OSPEDALIERA UNIVERSITARIA SENRESE

  公开号：US20190099403A1

  公开（公告）日：2019-04-04

  The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents. (I) or (II)
• HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS
  申请人：AZIENDA OSPEDALIERA UNIVERSITARIA SENESE

  公开号：US20200140398A1

  公开（公告）日：2020-05-07

  The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.