Tetrakis[2-[2-(2-hydroxyethoxy)ethoxy]ethyl] tritriacontacyclo[10.7.7.62,4.46,7.313,15.317,19.23,20.29,11.210,26.222,24.15,8.014,25.016,23.018,21.734,41.229,43.130,31.138,39.027,46.028,42.029,46.032,45.033,59.035,36.037,53.040,49.044,62.048,56.050,52.050,57.052,61.054,58.055,60]dohexaconta-1,3,5,7,9,11(39),12(26),13,15,17(35),18,20,22,24,27,30(62),31,33,36,38(61),40(49),41(48),42,44,53,55(60),56,58-octacosaene-47,47,51,51-tetracarboxylate | 1000074-96-3

分子结构分类

有机化合物 - 苯类化合物 - 菲及其衍生物

中文名称

——

中文别名

——

英文名称

Tetrakis[2-[2-(2-hydroxyethoxy)ethoxy]ethyl] tritriacontacyclo[10.7.7.62,4.46,7.313,15.317,19.23,20.29,11.210,26.222,24.15,8.014,25.016,23.018,21.734,41.229,43.130,31.138,39.027,46.028,42.029,46.032,45.033,59.035,36.037,53.040,49.044,62.048,56.050,52.050,57.052,61.054,58.055,60]dohexaconta-1,3,5,7,9,11(39),12(26),13,15,17(35),18,20,22,24,27,30(62),31,33,36,38(61),40(49),41(48),42,44,53,55(60),56,58-octacosaene-47,47,51,51-tetracarboxylate

英文别名

——

Tetrakis[2-[2-(2-hydroxyethoxy)ethoxy]ethyl] tritriacontacyclo[10.7.7.62,4.46,7.313,15.317,19.23,20.29,11.210,26.222,24.15,8.014,25.016,23.018,21.734,41.229,43.130,31.138,39.027,46.028,42.029,46.032,45.033,59.035,36.037,53.040,49.044,62.048,56.050,52.050,57.052,61.054,58.055,60]dohexaconta-1,3,5,7,9,11(39),12(26),13,15,17(35),18,20,22,24,27,30(62),31,33,36,38(61),40(49),41(48),42,44,53,55(60),56,58-octacosaene-47,47,51,51-tetracarboxylate化学式

CAS

1000074-96-3

化学式

C₉₀H₅₂O₂₀

mdl

——

分子量

1453.39

InChiKey

ULJHQIGOMDGCEN-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

11.1
重原子数：

110
可旋转键数：

40
环数：

34.0
sp3杂化的碳原子比例：

0.33
拓扑面积：

260
氢给体数：

4
氢受体数：

20

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	Tetrakis[2-[2-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]ethoxy]ethyl] tritriacontacyclo[10.7.7.62,4.46,7.313,15.317,19.23,20.29,11.210,26.222,24.15,8.014,25.016,23.018,21.734,41.229,43.130,31.138,39.027,46.028,42.029,46.032,45.033,59.035,36.037,53.040,49.044,62.048,56.050,52.050,57.052,61.054,58.055,60]dohexaconta-1,3,5,7,9,11(39),12(26),13,15,17(35),18,20,22,24,27,30(62),31,33,36,38(61),40(49),41(48),42,44,53,55(60),56,58-octacosaene-47,47,51,51-tetracarboxylate	1000074-92-9	C₁₁₄H₁₀₈O₂₀Si₄	1910.44

反应信息

作为产物：

描述：

Tetrakis[2-[2-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]ethoxy]ethyl] tritriacontacyclo[10.7.7.62,4.46,7.313,15.317,19.23,20.29,11.210,26.222,24.15,8.014,25.016,23.018,21.734,41.229,43.130,31.138,39.027,46.028,42.029,46.032,45.033,59.035,36.037,53.040,49.044,62.048,56.050,52.050,57.052,61.054,58.055,60]dohexaconta-1,3,5,7,9,11(39),12(26),13,15,17(35),18,20,22,24,27,30(62),31,33,36,38(61),40(49),41(48),42,44,53,55(60),56,58-octacosaene-47,47,51,51-tetracarboxylate 在盐酸作用下，以四氢呋喃为溶剂，以69%的产率得到Tetrakis[2-[2-(2-hydroxyethoxy)ethoxy]ethyl] tritriacontacyclo[10.7.7.62,4.46,7.313,15.317,19.23,20.29,11.210,26.222,24.15,8.014,25.016,23.018,21.734,41.229,43.130,31.138,39.027,46.028,42.029,46.032,45.033,59.035,36.037,53.040,49.044,62.048,56.050,52.050,57.052,61.054,58.055,60]dohexaconta-1,3,5,7,9,11(39),12(26),13,15,17(35),18,20,22,24,27,30(62),31,33,36,38(61),40(49),41(48),42,44,53,55(60),56,58-octacosaene-47,47,51,51-tetracarboxylate

参考文献：

名称：

C60和C70的四面体加合物的水溶性，抗氧化活性和细胞色素C结合。

摘要：

在过去的十年中，许多不同的研究人员表明，经表面修饰的水溶性富勒烯在体外对活性氧（ROS）表现出强大的抗氧化活性，并在体内保护细胞和组织免受氧化损伤和细胞死亡。然而，开发富勒烯作为真正的候选药物的进展受到三个发展问题的阻碍：1）缺乏可扩展合成的方法；2）无法生产与药物应用兼容的高度纯化的单一物种区域异构体；和3）对于各种表面修饰（例如，阴离子对阳离子对电荷中性极性）对结构-功能关系的理解不足。为了应对这些挑战，我们已经设计并合成了十多种新型水溶性富勒烯，它们可以作为单一异构体进行纯化，我们相信可以以合理的成本进行规模生产。这些化合物的添加方式，亲脂性以及电荷的数量和类型不同，并检查了它们的水溶性，对超氧阴离子的抗氧化活性和细胞色素C的结合。我们的结果表明，树状水溶性富勒烯[60]单加合物表现出最高程度的与三羟甲基磺酸盐衍生的阴离子富勒烯以及总体结构相似的阳离子富勒烯相比，其抗超氧阴离子的体外

DOI：

10.1039/b711912g

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分子结构分类

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上下游信息

反应信息

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