1-(2,4-Dimethyl-1,3-thiazole-5-sulfonyl)piperidine | 936083-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2,4-Dimethyl-1,3-thiazole-5-sulfonyl)piperidine
• 英文别名: 2,4-dimethyl-5-piperidin-1-ylsulfonyl-1,3-thiazole
• CAS: 936083-16-8
• 化学式: C₁₀H₁₆N₂O₂S₂
• 分子量: 260.4
• InChiKey: MUUYPJFOHKNNRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Small Molecule Sensitization of BAX Activation for Induction of Cell Death
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20200172530A1

  公开（公告）日：2020-06-04

  Provided herein are compositions comprising a compound of Formulas I, II, or III, and compositions a compound comprising a moiety of Formula IV, which are useful for sensitizing and/or activating pro-apoptotic activity of BAX. Methods of treating diseases associated with BAX (e.g., cancer) and methods of identifying compounds which sensitize and/or activate the pro-apoptotic activity of a BAX polypeptide are also provided.