2-((2-bromophenoxy)methyl)pyridine | 1016531-68-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-((2-bromophenoxy)methyl)pyridine
• 英文别名: 2-[(2-bromophenoxy)methyl]pyridine
• CAS: 1016531-68-2
• 化学式: C₁₂H₁₀BrNO
• 分子量: 264.121
• InChiKey: APVLSMPTXATIRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-((2-bromophenoxy)methyl)pyridine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 磺酰氯 、 溶剂黄146 、 N,N-二异丙基乙胺 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 2.25h， 生成 2-(pyridin-2-ylmethoxy)benzenesulfonyl chloride
  参考文献：
  名称：

  [EN] FUSED BENZOISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS
  [FR] COMPOSÉS BENZOISOXAZOLYLE FUSIONNÉS EN TANT QU'INHIBITEURS DE KAT6A

  摘要：

  The present invention provides fused benzoisoxazolyl compounds represented by compound of formula (I), which are therapeutically useful as KAT6A inhibitors particularly in the treatment and/or prevention of the diseases or disorders mediated by KAT6A in a subject. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt or a stereoisomer or a tautomer thereof.

  公开号：

  WO2023114710A1
• 作为产物：
  描述：

  2-氯甲基吡啶 、 2-溴苯酚 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以91.71 %的产率得到2-((2-bromophenoxy)methyl)pyridine
  参考文献：
  名称：

  [EN] FUSED BENZOISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS
  [FR] COMPOSÉS BENZOISOXAZOLYLE FUSIONNÉS EN TANT QU'INHIBITEURS DE KAT6A

  摘要：

  The present invention provides fused benzoisoxazolyl compounds represented by compound of formula (I), which are therapeutically useful as KAT6A inhibitors particularly in the treatment and/or prevention of the diseases or disorders mediated by KAT6A in a subject. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt or a stereoisomer or a tautomer thereof.

  公开号：

  WO2023114710A1

文献信息

• [EN] FUSED BENZOISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS<br/>[FR] COMPOSÉS BENZOISOXAZOLYLE FUSIONNÉS EN TANT QU'INHIBITEURS DE KAT6A
  申请人：[en]AURIGENE ONCOLOGY LIMITED

  公开号：WO2023114710A1

  公开（公告）日：2023-06-22

  The present invention provides fused benzoisoxazolyl compounds represented by compound of formula (I), which are therapeutically useful as KAT6A inhibitors particularly in the treatment and/or prevention of the diseases or disorders mediated by KAT6A in a subject. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt or a stereoisomer or a tautomer thereof.