dibenzyl [(2R)-2-[(4S)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxolan-4-yl]-2-phenylmethoxyethyl] phosphate | 1005155-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibenzyl [(2R)-2-[(4S)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxolan-4-yl]-2-phenylmethoxyethyl] phosphate
• CAS: 1005155-51-0
• 化学式: C₃₄H₃₇O₈P
• 分子量: 604.637
• InChiKey: QHIZGUPEOHOTBB-FVQYSQFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  43
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  dibenzyl [(2R)-2-[(4S)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxolan-4-yl]-2-phenylmethoxyethyl] phosphate 在 palladium dihydroxide 氢气 作用下， 以 乙醇 为溶剂， 以81%的产率得到(2R,3S)-2,3,4-三羟基-3-甲基丁基磷酸二氢酯
  参考文献：
  名称：

  Synthesis of enantiopure 2-C-methyl-d-erythritol-4-phosphate

  摘要：

  The synthesis of enantiopure 2-C-methyl-D-erythritol-4-phosphate is disclosed. A 1,3-diol possessing a quaternary stereogenic centre, prepared stereo selectively from an acyclic tri-substituted alkene, has been utilized as a key intermediate. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.129
• 作为产物：
  描述：

  (2R)-2-[(4S)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxolan-4-yl]-2-phenylmethoxyethanol 、 二苄基磷酰基氯 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到dibenzyl [(2R)-2-[(4S)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxolan-4-yl]-2-phenylmethoxyethyl] phosphate
  参考文献：
  名称：

  Synthesis of enantiopure 2-C-methyl-d-erythritol-4-phosphate

  摘要：

  The synthesis of enantiopure 2-C-methyl-D-erythritol-4-phosphate is disclosed. A 1,3-diol possessing a quaternary stereogenic centre, prepared stereo selectively from an acyclic tri-substituted alkene, has been utilized as a key intermediate. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.129

文献信息

• Synthesis of enantiopure 2-C-methyl-d-erythritol-4-phosphate
  作者：Sadagopan Raghavan、T. Sreekanth

  DOI：10.1016/j.tetlet.2007.10.129

  日期：2007.12

  The synthesis of enantiopure 2-C-methyl-D-erythritol-4-phosphate is disclosed. A 1,3-diol possessing a quaternary stereogenic centre, prepared stereo selectively from an acyclic tri-substituted alkene, has been utilized as a key intermediate. (C) 2007 Elsevier Ltd. All rights reserved.