methyl 1-tosylpiperidin-4-yl phenylcarbonimidodithioate | 1013632-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 1-tosylpiperidin-4-yl phenylcarbonimidodithioate
• 英文别名: 1-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]sulfanyl-1-methylsulfanyl-N-phenylmethanimine
• CAS: 1013632-27-3
• 化学式: C₂₀H₂₄N₂O₂S₃
• 分子量: 420.621
• InChiKey: JLRONAXHIGPFAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl phenyl(1-tosylpiperidine-4-carbonyloxy)carbamodithioate 以 二氯甲烷 为溶剂， 反应 2.0h， 以84%的产率得到methyl 1-tosylpiperidin-4-yl phenylcarbonimidodithioate
  参考文献：
  名称：

  Decarboxylative Radical Azidation Using MPDOC and MMDOC Esters

  摘要：

  An efficient radical-mediated decarboxylative azidation of aliphatic carboxylic acids has been developed. The success of this transformation hinges on the use of a new type of thiohydroxamate esters (MPDOC esters). These esters are more stable than the classical Barton esters and less prone to rearrange under radical conditions. In the case of alpha-alkoxy and alpha-amino acids, optimal results are obtained with the even more stable MMDOC esters developed recently by Kim.

  DOI：

  10.1021/ol702832x

文献信息

• Decarboxylative Radical Azidation Using MPDOC and MMDOC Esters
  作者：Erich Nyfeler、Philippe Renaud

  DOI：10.1021/ol702832x

  日期：2008.3.1

  An efficient radical-mediated decarboxylative azidation of aliphatic carboxylic acids has been developed. The success of this transformation hinges on the use of a new type of thiohydroxamate esters (MPDOC esters). These esters are more stable than the classical Barton esters and less prone to rearrange under radical conditions. In the case of alpha-alkoxy and alpha-amino acids, optimal results are obtained with the even more stable MMDOC esters developed recently by Kim.