3-(5-Methyl-2-thienyl)-N'-(4-pyridinylmethylene)-1H-pyrazole-5-carbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(5-Methyl-2-thienyl)-N'-(4-pyridinylmethylene)-1H-pyrazole-5-carbohydrazide
• 英文别名: 5-(5-methylthiophen-2-yl)-N-[(E)-pyridin-4-ylmethylideneamino]-1H-pyrazole-3-carboxamide
• 化学式: C₁₅H₁₃N₅OS
• 分子量: 311.4
• InChiKey: WZHSVZHJUQZGTC-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Small molecule modulators of the cold and menthol receptor TRPM8
  申请人：B.R.A.I.N. Biotechnology Research And Information Network AG

  公开号：EP2497458A1

  公开（公告）日：2012-09-12

  The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body. In particular, the present invention relates to the use of compounds modulating TRPM8, and optionally to the use of compounds selectively exhibiting agonist activity at the TRPM8 channel. Such compounds have applications in many fields, particularly in oral and personal hygiene products and foodstuffs, but also in pharmaceutical composition products, cosmetics, textile products and packaging products. The present invention further relates to products containing such compounds and to the medical use of such compounds.

  本发明涉及当与人体接触时能够产生冷却感的化合物的用途。特别是，本发明涉及调节 TRPM8 的化合物的使用，以及选择性地在 TRPM8 通道表现出激动剂活性的化合物的使用。这类化合物可应用于许多领域，特别是口腔和个人卫生用品和食品，也可应用于药物组合产品、化妆品、纺织品和包装产品。本发明还涉及含有此类化合物的产品以及此类化合物的医疗用途。
• SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8
  申请人：B.R.A.I.N. Biotechnology Research And Information Network AG

  公开号：EP2683352B1

  公开（公告）日：2016-10-26
• US9585865B2
  申请人：——

  公开号：US9585865B2

  公开（公告）日：2017-03-07
• [EN] SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8<br/>[FR] MODULATEURS À PETITES MOLÉCULES DU FROID ET RÉCEPTEUR AU MENTHOL TRPM8
  申请人：BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG

  公开号：WO2012120099A2

  公开（公告）日：2012-09-13

  The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body. In particular, the present invention relates to the use of compounds modulating TRPM8, and optionally to the use of compounds selectively exhibiting agonist activity at the TRPM8 channel. Such compounds have applications in many fields, particularly in oral and personal hygiene products and foodstuffs, but also in pharmaceutical composition products, cosmetics, textile products and packaging products. The present invention further relates to products containing such compounds and to the medical use of such compounds.