4-(2-chlorobenzyl)-N-[(E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]piperazin-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-chlorobenzyl)-N-[(E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]piperazin-1-amine
• 英文别名: (E)-N-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
• 化学式: C₂₃H₂₆ClN₅
• 分子量: 407.9
• InChiKey: AFTWKQIYGDIQGK-PCLIKHOPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Modulators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
  申请人：Beachy Philip A.

  公开号：US20100069386A1

  公开（公告）日：2010-03-18

  The present invention makes available methods and reagents for inhibiting aberrant growth states resulting form hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. Such methods and reagents may also inhibit the hedgehog pathway in normal cells, e.g., where normal levels of hedgehog signalling are unwanted.
• GANGLIOSIDE BIOSYNTHESIS MODULATORS
  申请人：CRAWFORD Brett E.

  公开号：US20100248365A1

  公开（公告）日：2010-09-30

  Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation.
• US7655674B2
  申请人：——

  公开号：US7655674B2

  公开（公告）日：2010-02-02