N'~1~-[(E)-1-(1,3-Diphenyl-1H-pyrazol-4-YL)methylidene]-2-{[4-phenyl-5-(4-pyridyl)-4H-1,2,4-triazol-3-YL]sulfanyl}acetohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N'~1~-[(E)-1-(1,3-Diphenyl-1H-pyrazol-4-YL)methylidene]-2-{[4-phenyl-5-(4-pyridyl)-4H-1,2,4-triazol-3-YL]sulfanyl}acetohydrazide
• 英文别名: N-[(E)-(1,3-diphenylpyrazol-4-yl)methylideneamino]-2-[(4-phenyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
• 化学式: C₃₁H₂₄N₈OS
• 分子量: 556.6
• InChiKey: DDISZPFVNPVLJI-FMFFXOCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Transcription factor modulating compounds and methods of use thereof
  申请人：Levy Stuart B.

  公开号：US20090131401A1

  公开（公告）日：2009-05-21

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了可用作抗感染剂的取代苯并咪唑化合物，其可降低微生物的耐药性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及其制备的药物制剂，例如用于减少抗生素耐药性和抑制生物膜的制剂。
• 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE
  申请人：Wis Ta Laboratories Ltd.

  公开号：US20140221359A1

  公开（公告）日：2014-08-07

  Described are methods of prepraing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R 1 and R 9 are independently selected from: —H; C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 1-4 alkyl; each of R 3NA and R 3NB is independently selected from: —H; C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 1-4 alkyl; each of R 7NA and R 7NB is independently selected from: —H; C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 1-4 alkyl; each of HX 1 and HX 2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

  本文描述了制备式为的还原型3,7-二氨基-10H-苯并噻嗪（DAPTZ）化合物的方法：其中：R1和R9独立地选自：—H；C1-4烷基；C2-4烯基；和卤代C1-4烷基；每个R3NA和R3NB独立地选自：—H；C1-4烷基；C2-4烯基；和卤代C1-4烷基；每个R7NA和R7NB独立地选自：—H；C1-4烷基；C2-4烯基；和卤代C1-4烷基；每个HX1和HX2独立地为质子酸；以及其药学上可接受的盐、溶剂化合物和水合物。这些方法特别适用于生产稳定的还原型，且具有高纯度。稳定性和纯度对于治疗疾病的制药组合物尤为重要。该化合物可用于治疗tau病理学，例如阿尔茨海默病，并且还可作为相应氧化硫烯药物的前药。
• US7405235B2
  申请人：——

  公开号：US7405235B2

  公开（公告）日：2008-07-29