1-Methyl-6-methoxy-1,2,3,4-tetrahydroquinoxaline | 912284-84-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Methyl-6-methoxy-1,2,3,4-tetrahydroquinoxaline
• 英文别名: 7-methoxy-4-methyl-2,3-dihydro-1H-quinoxaline
• CAS: 912284-84-5
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: LPBMGEDTFJIZLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-碘基-3-硝基苯甲醚 在 copper(l) iodide 、 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 cesium acetate 、 potassium carbonate 、 溶剂黄146 、 锌 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 72.0h， 生成 1-Methyl-6-methoxy-1,2,3,4-tetrahydroquinoxaline
  参考文献：
  名称：

  Preparation of substituted 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines from catalytic Cp∗Ir hydrogen transfer N-heterocyclization of anilino alcohols

  摘要：

  The [Cp*IrCl2](2)/K2CO3 catalyzed hydrogen transfer N-heterocyclization on a series of anilino alcohols has been investigated. The catalyst (20% loading) converts anilino alcohols to 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines in 30-84% isolated yield. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.07.033

文献信息

• ACYLATED 4-AMINOPIPERIDINES AS INHIBITORS OF SERINE PALMITOYLTRANSFERASE
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP3287441B1

  公开（公告）日：2021-06-09
• Preparation of substituted 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines from catalytic Cp∗Ir hydrogen transfer N-heterocyclization of anilino alcohols
  作者：C. Todd Eary、Dane Clausen

  DOI：10.1016/j.tetlet.2006.07.033

  日期：2006.9

  The [Cp*IrCl2](2)/K2CO3 catalyzed hydrogen transfer N-heterocyclization on a series of anilino alcohols has been investigated. The catalyst (20% loading) converts anilino alcohols to 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines in 30-84% isolated yield. (c) 2006 Published by Elsevier Ltd.