(2R)-7-chloro-2-phenyl-2,3-dihydrochromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2R)-7-chloro-2-phenyl-2,3-dihydrochromen-4-one
• 化学式: C₁₅H₁₁ClO₂
• 分子量: 258.7
• InChiKey: MNJMPYFBQOISEB-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel intermediates and process for their preparation
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0051061A2

  公开（公告）日：1982-05-05

  Known and novel compounds of formula (I), wherein R, and R2 represent substituents selected from halogen atoms and nitro, cyano, trifluoromethyl, lower alkyl, lower alkoxyl, amino and hydroxyl groups are active against viruses, especially rhinoviruses. Methods for producing the compounds are described, as are pharmaceutical formulations and methods for administering the compounds to cure or prevent rhinoviral infections.

  已知的和新型的式 (I) 化合物，其中 R 和 R2 代表选自卤素原子和硝基、氰基、三氟甲基、低级烷基、低级烷氧基、氨基和羟基的取代基，对病毒，特别是鼻病毒具有活性。 描述了生产这些化合物的方法，以及使用这些化合物治疗或预防鼻病毒感染的药物制剂和方法。
• Anti-mycobacterium compositions and methods of preparing and using same
  申请人：Advanced Life Sciences, Inc.

  公开号：US20040147597A1

  公开（公告）日：2004-07-29

  The present invention relates to compounds, compositions and methods for the prevention or treatment of mycobacterium infections. The compounds are naturally occurring and synthetic biflavonoids, flavonoids, chalcones and chalcone like compounds. The compounds were screened for anti-mycobacterium activity. Of the compounds showing anti-mycobacterium activity, eight were identified as particularly potent, exhibiting greater than 90% inhibition of the growth of Mtb at a concentration of 12.5 Πg/mL. The actual minimum inhibitory concentrations (MIC), defined as the lowest concentration inhibiting 99% of the inoculum, for the preferred compounds ranged from 6.8 to 48.3 ΠM. 1

  本发明涉及预防或治疗分枝杆菌感染的化合物、组合物和方法。这些化合物是天然存在和合成的双黄酮类、黄酮类、查尔酮类和查尔酮类化合物。对这些化合物进行了抗分枝杆菌活性筛选。在显示出抗霉菌活性的化合物中，有 8 种被确定为特别有效，在浓度为 12.5 Πg/mL 时，对 Mtb 生长的抑制率超过 90%。优选化合物的实际最低抑菌浓度（MIC），即抑制接种体 99% 生长的最低浓度，介于 6.8 至 48.3 ΠM 之间。 1
• Flavans, process for their preparation and pharmaceutical compositions containing them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0004579B1

  公开（公告）日：1982-08-18
• US4461907A
  申请人：——

  公开号：US4461907A

  公开（公告）日：1984-07-24
• US6677350B1
  申请人：——

  公开号：US6677350B1

  公开（公告）日：2004-01-13