Amiothiadiazines | 1018074-74-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Amiothiadiazines
• 英文别名: 3-(2,4-dichloro-5-fluorophenyl)-N-(2,4-dichlorophenyl)-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-imine
• CAS: 1018074-74-2
• 化学式: C₁₆H₈Cl₄FN₅S
• 分子量: 463.149
• InChiKey: LEYOGRFLQHZBQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  80.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-[[4-amino-5-(2,4-dichloro-5-fluorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,4-dichlorophenyl)acetamide 在 三氯氧磷 作用下， 以80%的产率得到Amiothiadiazines
  参考文献：
  名称：

  Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines

  摘要：

  Dichlorofluorophenyl containing aminotriazolothiadiazines (6) were synthesized by initial condensation of 2-chloro-N-(substituted phenyl) acetamides (4) with triazole (3) and further cyclization using POCl3. The structures of newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Compounds 5a, 5e, 5n, 5o, 6a, 6n, and 6o showed very good antibacterial and antifungal activities at 6.25 mu g/ml concentrations. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.03.024

文献信息

• Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines
  作者：Mari Sithambaram Karthikeyan、Bantwal Shivarama Holla、Nalilu Suchetha Kumari

  DOI：10.1016/j.ejmech.2007.03.024

  日期：2008.2

  Dichlorofluorophenyl containing aminotriazolothiadiazines (6) were synthesized by initial condensation of 2-chloro-N-(substituted phenyl) acetamides (4) with triazole (3) and further cyclization using POCl3. The structures of newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Compounds 5a, 5e, 5n, 5o, 6a, 6n, and 6o showed very good antibacterial and antifungal activities at 6.25 mu g/ml concentrations. (c) 2007 Elsevier Masson SAS. All rights reserved.