4-[3-Oxo-3-(2,4,6-trihydroxyphenyl)propyl]phenyl dihydrogen phosphate | 51146-50-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-[3-Oxo-3-(2,4,6-trihydroxyphenyl)propyl]phenyl dihydrogen phosphate
• 英文别名: [4-[3-oxo-3-(2,4,6-trihydroxyphenyl)propyl]phenyl] dihydrogen phosphate
• CAS: 51146-50-0
• 化学式: C₁₅H₁₅O₈P
• 分子量: 354.25
• InChiKey: LPMSHKLLSREILJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Method and material for prevention of surgical adhesions
  申请人：JOHNSON & JOHNSON MEDICAL, INC.

  公开号：EP0213563A2

  公开（公告）日：1987-03-11

  An absorbable fabric which effectively reduces the incidence of postoperative adhesions when used as a physical barrier at the operative site is a warp knit fabric of oxidized regenerated cellulose or other bioresorbable material. The barrier fabric is particularly characterized by having a density of 8 to 15 mg/cm2 and an open area porosity of 12 to 20 percent.

  一种可吸收织物是由氧化再生纤维素或其他生物可吸收材料制成的经编织物，这种织物作为手术部位的物理屏障，可有效降低术后粘连的发生率。这种屏障织物的特点是密度为 8 至 15 毫克/平方厘米，开孔率为 12%至 20%。
• Heparin-containing adhesion prevention barrier and process
  申请人：JOHNSON & JOHNSON MEDICAL, INC.

  公开号：EP0262890A2

  公开（公告）日：1988-04-06

  An improved adhesion-preventative barrier fabric comprising an oxidized regenerated cellulose (ORC) fabric (or matrix having equivalent properties) which is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which fabric has heparin absorbed thereon, said heparin being present in a non-toxic, adhesion-­preventative, effective amount and potency; and, the process of using said improved barrier fabric or matrix to administer heparin to prevent surgical adhesions.

  一种改进的预防粘连屏障织物，由氧化再生纤维素（ORC）织物（或具有同等特性的基质）组成，该织物可悬垂、保形、粘附于身体器官，并可在体内三十（30）天内被大量吸收，该织物上吸收有肝素，所述肝素以无毒、预防粘连、有效的量和效力存在；以及使用所述改进的屏障织物或基质注射肝素以预防手术粘连的工艺。
• Low molecular weight heparin, heparinoid and hexuronyl hexosaminoglycan sulfate containing adhesion prevention barrier and process
  申请人：JOHNSON & JOHNSON PATIENT CARE, INC.

  公开号：EP0372969A1

  公开（公告）日：1990-06-13

  An improved adhesion-preventative barrier fabric comprising an oxidized regenerated cellulose (ORC) fabric (or matrix having equivalent properties) which is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which fabric has low molecular weight heparin, heparinoid or hexuronyl hexosaminoglycan sulfate active absorbed thereon, said active being present in a non-toxic, adhesion-preventative, effective amount and potency; and, the process of using said improved barrier fabric or matrix to administer low molecular weight heparin, heparinoid or hexuronyl hexosaminoglycan sulfate to prevent surgical adhesions.

  一种改良的预防粘连屏障织物，由氧化再生纤维素（ORC）织物（或具有同等性能的基质）组成，该织物可悬垂、保形、粘附于身体器官，并可在体内三十（30）天内基本被吸收，该织物上吸收有低分子量肝素、肝素类或六壬基六氨基多糖硫酸盐活性物质，所述活性物质以无毒、预防粘连、有效的量和效力存在；以及，使用所述改良的屏障织物或基质来施用低分子量肝素、肝素类或硫酸己醛基己胺多糖以防止手术粘连的工艺。
• DENDRIMERS WITH INTERIOR AND EXTERIOR FUNCTIONALITIES COMPRISING OF AZIDE OR ALKYNE GROUPS FOR POST- FUNCTIONALIZATION BY HUISGEN CLICK CYCLOADDITION
  申请人：Polymer Factory Sweden Ab

  公开号：EP2274362A1

  公开（公告）日：2011-01-19
• THERMOFORMED POLYMERIC ARTICLES CONTAINING AN ADDITIVE
  申请人：Diania Technologies Limited

  公开号：EP3394189A1

  公开（公告）日：2018-10-31