2-Ethyl-6-(4-methoxyphenyl)-4-methylcarbamoyl-2H-pyridazin-3-one | 243861-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Ethyl-6-(4-methoxyphenyl)-4-methylcarbamoyl-2H-pyridazin-3-one
• 英文别名: 2-ethyl-6-(4-methoxyphenyl)-N-methyl-3-oxopyridazine-4-carboxamide
• CAS: 243861-98-5
• 化学式: C₁₅H₁₇N₃O₃
• 分子量: 287.318
• InChiKey: HHDGDEKTEHTNNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-ethyl-4-methoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one 以82.8%的产率得到2-Ethyl-6-(4-methoxyphenyl)-4-methylcarbamoyl-2H-pyridazin-3-one
  参考文献：
  名称：

  Pyridazine derivatives and drugs containing the same as the active ingredient

  摘要：

  这项发明涉及由式（1）表示的吡啶嗪衍生物： 其中R1代表较低的烷氧基团、较低的烷硫基团或卤原子；R2代表H、较低的烷氧基团、较低的烷硫基团或卤原子；R3代表较低的烷基或较低的烯基，可以被一个或多个OH、CN、较低的环烷基、（取代的）芳香基或（取代的）氨基甲酰基取代；R4代表COOH、较低的烷氧羰基团、（取代的）氨基甲酰基、（取代的）氨基团或（取代的）脲基；虚线表示4位和5位之间的碳-碳键是单键或双键，或其盐；以及含有它们作为有效成分的药物。这些化合物对白细胞介素-1β的产生具有出色的抑制活性，并可用作免疫系统疾病、炎症性疾病、缺血性疾病等的预防和治疗药物。

  公开号：

  US06403586B1

文献信息

• Method of preparing a polymeric latex composition
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0308233A2

  公开（公告）日：1989-03-22

  A polymeric latex composition having a hydrophobe incorporated therein can be prepared using a novel method for incorporating the hydrophobe into the latex particles. This method includes providing a loadable latex, providing a hydrophobe dissolved in a water-miscible organic solvent, heating the loadable latex to 30 to 90°C and gradually adding the hydrophobe solution to the heated loadable latex under conditions to keep the hydrophobe in solution and to "load" or incorporate it into the latex particles. The latex can be surfactant-free and have particles which have outer reactive groups which are capable of reacting with free amine or sulfhydryl groups of a biological compound. Such latices can be used to prepare water-insoluble biological reagents having a biological compound attached to the particles.

  使用一种将憎水剂掺入胶乳颗粒的新方法，可以制备出含有憎水剂的聚合物胶乳组合物。该方法包括提供一种可负载胶乳，提供一种溶于水溶性有机溶剂中的憎水剂，将可负载胶乳加热至 30 至 90°C，并在使憎水剂保持在溶液中的条件下逐渐将憎水剂溶液添加到加热的可负载胶乳中，以将其 "负载 "或掺入胶乳颗粒中。这种胶乳可以不含表面活性剂，其颗粒的外部活性基团能够与生物化合物的游离胺或巯基发生反应。这种胶乳可用于制备水不溶性生物试剂，其颗粒上附有生物化合物。
• Method for the purification of immunoreactive labeled thyroxine conjugates
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0467466A1

  公开（公告）日：1992-01-22

  A method for purifying immunoreactive labeled thyroxine conjugates using immobilied antibodies that are i) raised against an analogue of thyroxine (T4) and ii) cross-reactive with thyroxine.

  一种利用固定抗体纯化免疫反应标记甲状腺素共轭物的方法，这些抗体 i) 针对甲状腺素（T4）的类似物，ii) 与甲状腺素有交叉反应。
• Ligand analogs for immunoassays derived from dicarboxylic acid oxidation products
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0468591A2

  公开（公告）日：1992-01-29

  What is disclosed is a ligand analog comprising a dicarboxylic acid oxidation product of an immunologically reactive mono- or a polysaccharide having vicinal diols, to which a label or a support is appended through an amide or thioester linkage.

  所公开的是一种配体类似物，它由免疫反应性单糖或多糖的二羧酸氧化产物组成，该单糖或多糖具有邻位二醇，通过酰胺或硫酯连接，在其上附加标签或支持物。
• Diluent composition
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0525916A1

  公开（公告）日：1993-02-03

  An aqueous diluent composition for use in a diagnostic kit and method useful in detecting antibodies in biological specimens is provided. The composition is buffered to a pH of from 6 to 10 and comprises an unmodified protein or carbohydrate, a surfactant and a chemically modified, water-soluble protein or carbohydrate having a pl less than or equal to 5.

  本发明提供了一种水性稀释剂组合物，可用于检测生物样本中抗体的诊断试剂盒和方法。该组合物的 pH 值为 6 至 10，由未修饰的蛋白质或碳水化合物、表面活性剂和化学修饰的水溶性蛋白质或碳水化合物组成，其 pl 值小于或等于 5。
• Detection of amplified nucleic acid using secondary soluble helper oligonucleotides and test kit
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0546590A1

  公开（公告）日：1993-06-16

  A target nucleic acid can be amplified and detected using a water-insoluble capture probe having a short oligonucleotide (15-20 nucleotides) covalently attached to a polymeric particle, and one or more secondary oligonucleotides. The capture probe and secondary oligonucleotides are complementary to the target nucleic acid, although the sequences of complementarity are different. Moreover, each of the secondary oligonucleotides has a length which is equal to or greater than the length of the capture probe oligonucleotide. The secondary oligonucleotides are hybridized to the target nucleic acid either before or during hybridization of the target to the capture probe. The result is improved hybridization efficiency of capture probe and target nucleic acid.

  使用水不溶性捕获探针可扩增和检测目标核酸，捕获探针具有共价连接到聚合物颗粒上的短寡核苷酸（15-20 个核苷酸）和一个或多个辅助寡核苷酸。捕获探针和二级寡核苷酸与靶核酸互补，但互补序列不同。此外，每个辅助寡核苷酸的长度等于或大于捕获探针寡核苷酸的长度。二级寡核苷酸在目标核酸与捕获探针杂交之前或期间与目标核酸杂交。其结果是提高了捕获探针和靶核酸的杂交效率。