2-[2-(4-carbamimidoylbenzyloxy)-4-methyl-3-oxo-N-phenyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]acetic acid | 1056736-90-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(4-carbamimidoylbenzyloxy)-4-methyl-3-oxo-N-phenyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]acetic acid
• 英文别名: 2-(N-[2-[(4-carbamimidoylphenyl)methoxy]-4-methyl-3-oxo-1,4-benzoxazine-7-carbonyl]anilino)acetic acid
• CAS: 1056736-90-3
• 化学式: C₂₆H₂₄N₄O₆
• 分子量: 488.5
• InChiKey: VFLMZJNMYXEIDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  ethyl 2-[2-(4-carbamimidoylbenzyloxy)-4-methyl-3-oxo-N-phenyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]acetate 在 sodium hydroxide 、 水 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以88.2%的产率得到2-[2-(4-carbamimidoylbenzyloxy)-4-methyl-3-oxo-N-phenyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]acetic acid
  参考文献：
  名称：

  3,4-Dihydro-2H-1,4-benzoxazine Derivatives Combining Thrombin Inhibitory and Glycoprotein IIb/IIIa Receptor Antagonistic Activity as a Novel Class of Antithrombotic Compounds with Dual Function

  摘要：

  3,4-Dihydro-2H-1,4-benzoxazine derivatives possessing both thrombin inhibitory and glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonistic activities were obtained by combining mimetics of the D-Phe-Pro-Arg pharmacophore of thrombin inhibitors and the Arg-Gly-Asp pharmacophor of GPIIb/IIIa receptor antagonists in the same low molecular weight peptidomimetic compound. Systematic variation of the position of substituents around the 3,4-dihydro-2H-1,4-benzoxazine nucleus, the distance between the carboxylate and amidine moieties, together with additional substituents to fill the thrombin S-2 and S-3 pockets resulted in compounds displaying submicromolar inhibition constants (K-i) for thrombin and submicromolar IC50 for inhibition of binding of fibrinogen to platelet GPIIb/IIIa receptor. Some of these compounds, such as 17a, 17b, 17d, and 17h possessing a well balanced activity at both targets, are a good starting point for further optimization. Incorporation of anticoagulant and platelet antiaggregatory activity in the same molecule constitutes a promising approach toward novel antithrombotic agents.

  DOI：

  10.1021/jm8003448

文献信息

• 3,4-Dihydro-2<i>H</i>-1,4-benzoxazine Derivatives Combining Thrombin Inhibitory and Glycoprotein IIb/IIIa Receptor Antagonistic Activity as a Novel Class of Antithrombotic Compounds with Dual Function
  作者：Janez Ilaš、Žiga Jakopin、Tina Borštnar、Mojca Stegnar、Danijel Kikelj

  DOI：10.1021/jm8003448

  日期：2008.9.25

  3,4-Dihydro-2H-1,4-benzoxazine derivatives possessing both thrombin inhibitory and glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonistic activities were obtained by combining mimetics of the D-Phe-Pro-Arg pharmacophore of thrombin inhibitors and the Arg-Gly-Asp pharmacophor of GPIIb/IIIa receptor antagonists in the same low molecular weight peptidomimetic compound. Systematic variation of the position of substituents around the 3,4-dihydro-2H-1,4-benzoxazine nucleus, the distance between the carboxylate and amidine moieties, together with additional substituents to fill the thrombin S-2 and S-3 pockets resulted in compounds displaying submicromolar inhibition constants (K-i) for thrombin and submicromolar IC50 for inhibition of binding of fibrinogen to platelet GPIIb/IIIa receptor. Some of these compounds, such as 17a, 17b, 17d, and 17h possessing a well balanced activity at both targets, are a good starting point for further optimization. Incorporation of anticoagulant and platelet antiaggregatory activity in the same molecule constitutes a promising approach toward novel antithrombotic agents.