Boc-Leu-Leu-N(Me)Leu-OBn | 1069132-29-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Leu-Leu-N(Me)Leu-OBn
• 英文别名: benzyl (2S)-4-methyl-2-[methyl-[(2S)-4-methyl-2-[[(2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]pentanoyl]amino]pentanoate
• CAS: 1069132-29-1
• 化学式: C₃₁H₅₁N₃O₆
• 分子量: 561.762
• InChiKey: GAPQPUWROPRIKM-GSDHBNRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  40
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Boc-Leu-Leu-N(Me)Leu-OBn 在 苯甲醚 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae Galaxaura filamentosa

  摘要：

  Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG(2) cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.

  DOI：

  10.1021/ol801799d
• 作为产物：
  描述：

  BOC-L-亮氨酸 、 (S)-2-[((S)-2-Amino-4-methyl-pentanoyl)-methyl-amino]-4-methyl-pentanoic acid benzyl ester 在 N,N-二异丙基乙胺 、 3-(二乙氧基邻酰氧基)-1,2,3-苯并三嗪-4-酮 作用下， 以 四氢呋喃 为溶剂， 生成 Boc-Leu-Leu-N(Me)Leu-OBn
  参考文献：
  名称：

  Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae Galaxaura filamentosa

  摘要：

  Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG(2) cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.

  DOI：

  10.1021/ol801799d

文献信息

• Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae <i>Galaxaura filamentosa</i>
  作者：Wen-Jie Xu、Xiao-Jian Liao、Shi-Hai Xu、Jian-Zhong Diao、Bin Du、Xu-Long Zhou、Shan-Shan Pan

  DOI：10.1021/ol801799d

  日期：2008.10.16

  Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG(2) cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.