3-(1H-imidazol-1-ium-1-yl)propan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(1H-imidazol-1-ium-1-yl)propan-1-amine
• 化学式: C6H12N3+
• 分子量: 126.18
• InChiKey: KDHWOCLBMVSZPG-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS
  申请人：Connor Eric

  公开号：US20140356316A1

  公开（公告）日：2014-12-04

  The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

  本发明提供了交联胺聚合物，用于有效地结合和清除胆盐从胃肠道。这些胆酸结合聚合物或其药物组合物可以被用于治疗各种疾病，包括高胆固醇血症、糖尿病、瘙痒、肠易激综合征-腹泻（IBS-D）、胆酸吸收不良等。
• US9655920B2
  申请人：——

  公开号：US9655920B2

  公开（公告）日：2017-05-23
• [EN] AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS<br/>[FR] POLYMÈRES D'AMINE POUR L'UTILISATION COMME SÉQUESTRANTS DE L'ACIDE BILIAIRE
  申请人：RELYPSA INC

  公开号：WO2011106548A1

  公开（公告）日：2011-09-01

  The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.