N-(4-(1H-pyrazol-4-yl)phenyl)chroman-3-carboxamide | 1093961-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(1H-pyrazol-4-yl)phenyl)chroman-3-carboxamide
• 英文别名: N-[4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-2H-chromene-3-carboxamide
• CAS: 1093961-37-5
• 化学式: C₁₉H₁₇N₃O₂
• 分子量: 319.363
• InChiKey: JJJJNDXIYADPOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS
  申请人：Feng Yangbo

  公开号：US20110150833A1

  公开（公告）日：2011-06-23

  Compounds useful as Rho kinase inhibitors of formula (1) wherein the variables are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.

  提供了一些公式（1）中变量的Rho激酶抑制剂，这些化合物可用于治疗由Rho激酶介导的疾病。还提供了制备这些化合物的方法和治疗Rho激酶介导的疾病的方法。
• COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF
  申请人：The Translational Genomics Research Institute

  公开号：US20160272587A1

  公开（公告）日：2016-09-22

  The invention provides compounds that inhibit ROCK activity. In certain embodiments the compounds of the invention enhance cognitive function. The invention is also directed to pharmaceutical compositions that comprise ROCK inhibitors and to methods enhance cognitive function and reducing and/or treat cognitive function decline.
• US9617214B2
  申请人：——

  公开号：US9617214B2

  公开（公告）日：2017-04-11
• [EN] BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS<br/>[FR] BENZOPYRANES ET ANALOGUES UTILISÉS COMME INHIBITEURS DE LA RHO KINASE
  申请人：FENG YANGBO

  公开号：WO2009079008A1

  公开（公告）日：2009-06-25

  Compounds useful as Rho kinase inhibitors of formula (I) wherein the variables are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.