2-chloro-5-(S-methylsulfonimidoylmethyl)thiazole | 1092391-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-chloro-5-(S-methylsulfonimidoylmethyl)thiazole
• 英文别名: (2-Chloro-1,3-thiazol-5-yl)methyl-imino-methyl-oxo-lambda6-sulfane；(2-chloro-1,3-thiazol-5-yl)methyl-imino-methyl-oxo-λ6-sulfane
• CAS: 1092391-10-0
• 化学式: C₅H₇ClN₂OS₂
• 分子量: 210.708
• InChiKey: KLEKLFMTTRFEBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-chloro-5-(S-methylsulfonimidoylmethyl)thiazole 、 甲基磺酰氯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以92%的产率得到N-methylsulfonyl-S-methyl-S-[(2-chloro-1,3-thiazol-5-yl)methyl] sulfoximine
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of N-Substituted (1,3-Thiazole)alkyl Sulfoximine Derivatives

  摘要：

  The N-substituted alkyl sulfoximine derivatives are a new chemical family of neonicotinoid insecticides. We have designed and synthesized 10 (1,3-thiazole)alkyl sulfoximine derivatives. All compounds were identified by H-1 and C-13 nuclear magnetic resonance (NMR), IR, and elemental analyses. Preliminary bioassays indicated that some title compounds exhibited good insecticidal activities at 10 mg/L against Myzus persicae. The relationship between structure and biological activity was also discussed.

  DOI：

  10.1021/jf802802g
• 作为产物：
  描述：

  2-chloro-5-(methylsulfinylmethyl)thiazole 在 sodium azide 作用下， 以 氯仿 、 硫酸 为溶剂， 以72%的产率得到2-chloro-5-(S-methylsulfonimidoylmethyl)thiazole
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of N-Substituted (1,3-Thiazole)alkyl Sulfoximine Derivatives

  摘要：

  The N-substituted alkyl sulfoximine derivatives are a new chemical family of neonicotinoid insecticides. We have designed and synthesized 10 (1,3-thiazole)alkyl sulfoximine derivatives. All compounds were identified by H-1 and C-13 nuclear magnetic resonance (NMR), IR, and elemental analyses. Preliminary bioassays indicated that some title compounds exhibited good insecticidal activities at 10 mg/L against Myzus persicae. The relationship between structure and biological activity was also discussed.

  DOI：

  10.1021/jf802802g

文献信息

• Synthesis and Insecticidal Activity of <i>N</i>-Substituted (1,3-Thiazole)alkyl Sulfoximine Derivatives
  作者：Haibo Yu、Zhenfang Qin、Hong Dai、Xin Zhang、Xue Qin、Tingting Wang、Jianxin Fang

  DOI：10.1021/jf802802g

  日期：2008.12.10

  The N-substituted alkyl sulfoximine derivatives are a new chemical family of neonicotinoid insecticides. We have designed and synthesized 10 (1,3-thiazole)alkyl sulfoximine derivatives. All compounds were identified by H-1 and C-13 nuclear magnetic resonance (NMR), IR, and elemental analyses. Preliminary bioassays indicated that some title compounds exhibited good insecticidal activities at 10 mg/L against Myzus persicae. The relationship between structure and biological activity was also discussed.