(6R,8S,8aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]hexahydro-8-hydroxy-2-methyl-8a-[[2-(trimethylsilyl)ethyl]thio]pyrrolo[1,2-a]pyrazine-1,4-dione | 1096711-44-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (6R,8S,8aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]hexahydro-8-hydroxy-2-methyl-8a-[[2-(trimethylsilyl)ethyl]thio]pyrrolo[1,2-a]pyrazine-1,4-dione
• 英文别名: (6R,8S,8aR)-6-[[tert-butyl(diphenyl)silyl]oxymethyl]-8-hydroxy-2-methyl-8a-(2-trimethylsilylethylsulfanyl)-3,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-1,4-dione
• CAS: 1096711-44-2
• 化学式: C₃₀H₄₄N₂O₄SSi₂
• 分子量: 584.927
• InChiKey: RJUQBJAPTCCTQV-RHSVSJCASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.76
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  95.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,4-二氢-2H-吡喃 、 (6R,8S,8aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]hexahydro-8-hydroxy-2-methyl-8a-[[2-(trimethylsilyl)ethyl]thio]pyrrolo[1,2-a]pyrazine-1,4-dione 在 对甲苯磺酸 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以92%的产率得到(6R,8S,8aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]hexahydro-2-methyl-8-[(tetrahydro-2H-pyran-2-yl)oxy]-8a-[[2-(trimethylsilyl)ethyl]thio]pyrrolo[1,2-a]pyrazine-1,4-dione
  参考文献：
  名称：

  Asymmetric Synthesis of the ABC-Ring System of the Antitumor Antibiotic MPC1001

  摘要：

  trans-4-Hydroxy-L-proline was converted into a tricyclic compound representing three contiguous rings of the anticancer antibiotic MPC1001. The tricyclic model contains the dihydrooxepin and diketopiperazine Subunits, as well as one of the Sulfur atoms of the natural product. The diketopiperazine unit was formed by a new method that involves cyclization of an enolate onto the carbonyl of a phenyl carbamate, and the dihydrooxepin ring was generated by using an acid-induced cyclization of an alcohol onto the beta-carbon of a vinylogous amide.

  DOI：

  10.1021/jo802344t
• 作为产物：
  描述：

  (6R,8aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]tetrahydro-2-methyl-8a-[[2-(trimethylsilyl)ethyl]thio]pyrrolo[1,2-a]pyrazine-1,4,8(8aH)-trione 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.75h， 以100%的产率得到(6R,8S,8aR)-6-[[(tert-butyldimethylsilyl)oxy]methyl]hexahydro-8-hydroxy-2-methyl-8a-[[2-(trimethylsilyl)ethyl]thio]pyrrolo[1,2-a]pyrazine-1,4-dione
  参考文献：
  名称：

  Asymmetric Synthesis of the ABC-Ring System of the Antitumor Antibiotic MPC1001

  摘要：

  trans-4-Hydroxy-L-proline was converted into a tricyclic compound representing three contiguous rings of the anticancer antibiotic MPC1001. The tricyclic model contains the dihydrooxepin and diketopiperazine Subunits, as well as one of the Sulfur atoms of the natural product. The diketopiperazine unit was formed by a new method that involves cyclization of an enolate onto the carbonyl of a phenyl carbamate, and the dihydrooxepin ring was generated by using an acid-induced cyclization of an alcohol onto the beta-carbon of a vinylogous amide.

  DOI：

  10.1021/jo802344t

文献信息

• Asymmetric Synthesis of the ABC-Ring System of the Antitumor Antibiotic MPC1001
  作者：Jianbiao Peng、Derrick L. J. Clive

  DOI：10.1021/jo802344t

  日期：2009.1.16

  trans-4-Hydroxy-L-proline was converted into a tricyclic compound representing three contiguous rings of the anticancer antibiotic MPC1001. The tricyclic model contains the dihydrooxepin and diketopiperazine Subunits, as well as one of the Sulfur atoms of the natural product. The diketopiperazine unit was formed by a new method that involves cyclization of an enolate onto the carbonyl of a phenyl carbamate, and the dihydrooxepin ring was generated by using an acid-induced cyclization of an alcohol onto the beta-carbon of a vinylogous amide.