1-[4-[[4-Amino-5-chloro-6-(2-propan-2-ylsulfonylanilino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinecarboxamide | 1125593-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[4-[[4-Amino-5-chloro-6-(2-propan-2-ylsulfonylanilino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinecarboxamide
• 英文别名: 1-[4-[[4-amino-5-chloro-6-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperidine-4-carboxamide
• CAS: 1125593-85-2
• 化学式: C₂₆H₃₂ClN₇O₄S
• 分子量: 574.1
• InChiKey: IMEGLYUXMGWVQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  174
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS<br/>[FR] PYRIMIDINE SUBSTITUÉE PAR AMINO, DÉRIVÉS DE PYROLLOPYRIDINE ET DE PYRAZOLOPYRIMIDINE UTILISÉS EN TANT QU'INHIBITEURS DE LA KINASE ET DANS LE TRAITEMENT DE TROUBLES PROLIFÉRATIFS ET DE MALADIES LIÉES À L'ANGIOGENÈSE
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2009032694A1

  公开（公告）日：2009-03-12

  This invention relates to novel amino subsituted pyrimidine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
• [EN] 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS INHIBITEURS DE KINASE
  申请人：IRM LLC

  公开号：WO2009032703A1

  公开（公告）日：2009-03-12

  This invention relates to novel amino substituted pyrimidine compounds of formula (I), pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.