丁香酸乙酯 | 3943-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 丁香酸乙酯
• 中文别名: 3,5-二甲氧基-4-羟基苯甲酸乙酯
• 英文名称: 4-hydroxy-3,5-dimethoxybenzoic acid ethyl ester
• 英文别名: ethyl 4-hydroxy-3,5-dimethoxybenzoate；syringic acid ethyl ester；ethyl syringate；4-hydroxy-3,5-dimethoxy-benzoic acid ethyl ester；4-Hydroxy-3,5-dimethoxy-benzoesaeure-aethylester；3.5-Dimethylaether-gallussaeure-aethylester
• CAS: 3943-80-4
• 化学式: C₁₁H₁₄O₅
• 分子量: 226.229
• InChiKey: WKUVKFZZCHINKG-UHFFFAOYSA-N

物化性质

• 熔点：
  93℃
• 保留指数：
  2932

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  丁香酸乙酯 在 2,6-二甲基吡啶 、 potassium carbonate 作用下， 以 乙醇 、 丁酮 为溶剂， 生成 8-{[[2-hydroxy-3-[(4-ethoxycarbonyl-2,6-dimethoxy)phenoxy]]propyl]thio}adenosine
  参考文献：
  名称：

  8-Substituted purine derivatives: a new class of lipid-lowering agents

  摘要：

  A series of purine derivatives have been prepared and their in vivo abilities to lower plasma total cholesterol and triglyceride levels, and to elevate high density lipoprotein (HDL) cholesterol levels in hyperlipemic rats have been tested. Some compounds, among which 8-{2-(R)-hydroxy-3-[(p-isobutoxycarbonyl)phenoxy]propylthio}adenosine 31, 8-{3-[(p-isobutoxy carbonyl)phenoxy]-2-oxopropylthio} adenosine 33 and 8-{3-[(p-isobutoxycarbonyl)phenoxy]-2-hydrazonecarboxamidepropylthio} adenosine 36 appear to be the most interesting, have been found to have both the desired profile of activity and no hepatotoxicity, when administered po at 50, 100 or 300 mg/kg. Compounds 31, 33 and 36, orally tested at the same doses in the 15-d test, lower triglyceride and VLDL/LDL (very low density lipoprotein/low density lipoprotein) cholesterol levels by 10-33% and 13-46%, respectively, and increase HDL-associated cholesterol levels by 10-32%. These molecules have been chosen for further pharmacological and toxicological evaluations.

  DOI：

  10.1016/0223-5234(94)90098-1
• 作为产物：
  描述：

  4-乙酰氧基-3,5-二甲氧基苯甲酰氯 在 吡啶 、 sodium hydroxide 、 水 作用下， 以 乙醇 、 苯 为溶剂， 反应 0.75h， 生成 丁香酸乙酯
  参考文献：
  名称：

  Jogia, Madhu K.; Vakamoce, Veikila; Weavers, Rex T., Australian Journal of Chemistry, 1985, vol. 38, # 7, p. 1009 - 1016

  摘要：

  DOI：

文献信息

• Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products
  作者：Kai Bao、Aixue Fan、Yi Dai、Liang Zhang、Weige Zhang、Maosheng Cheng、Xinsheng Yao

  DOI：10.1039/b916969e

  日期：——

  An efficient selective demethylation and debenzylation method for aryl methyl/benzyl ethers using magnesium iodide under solvent-free conditions has been developed and applied to the synthesis of natural flavone and biphenyl glycosides. A variety of functional groups including glycoside were tolerated under the reaction conditions. Experimental results indicated that the removal of an O-benzyl group

  一种使用芳基甲基/苄基醚的有效选择性脱甲基和脱苄基方法 碘化镁 在无溶剂条件下已开发并应用于天然的合成 黄酮和联苯糖苷。在反应条件下可以耐受包括糖苷在内的多种官能团。实验结果表明，无论它们是在羰基的间位还是对位，O-苄基的去除都比O-甲基的去除更容易。因此，对于同时带有苄氧基和甲氧基的底物可以实现选择性的脱苄基作用。
• Ligustrazine aromatic acid ether derivative, its preparation method, pharmaceutical composition, and application
  申请人：Li Jiaming

  公开号：US20100228029A1

  公开（公告）日：2010-09-09

  Ligustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is selected from aryl substituted aryl and substituted styryl, R is selected from hydrogen and alkyl with no more than 6 carbon atoms.

  利血平芳香酸醚衍生物I的通式，其制备方法，药物组成和应用，其中Ar选自芳基取代芳基和取代苯乙烯基，R选自氢和不超过6个碳原子的烷基。
• 4-((3, 5, 6-trimethylpyrazine-2-yl) methoxyl) benzoic acid and its derivatives
  申请人：——

  公开号：US08350033B2

  公开（公告）日：2013-01-08

  Ligustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is selected from aryl substituted aryl and substituted styryl, R is selected from hydrogen and alkyl with no more than 6 carbon atoms.

  Ligustrazine芳香酸醚衍生物的一般式I，其制备方法，药物组合物和应用，其中Ar选自取代芳基和取代苯乙烯基，R选自氢和不超过6个碳原子的烷基。
• Radiation-sensitive positive resist composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0358871A2

  公开（公告）日：1990-03-21

  A positive resist composition which comprises a 1,2-quinone diazide compound and an alkali-soluble resin containing a polyphenol compound (I) of the general formula: X-α-H      (I) wherein X is a group of the formula: and α is a divalent group which comprises a repeating unit of the formula: in which n is a number of not less than 1; a, b, c, d, e and f are the same or different and a number of 0-3, provided that d + f is not less than 1; R₁, R₂ and R₃ are the same or different and a C₁-C₁₈ alkyl group, a C₁-₁₈ alkoxy group, a carboxyl group or a halogen atom; R₄ is a hydrogen atom, a C₁-C₁₈ alkyl group or an aryl group, which which resist composition is sensitive to radiation and has good balance of sensitivity, resolving power and heat resistance.

  一种阳离子抗蚀剂组合物，它由 1，2-醌二叠氮化合物和含有通式为 X-α-H (I) 其中 X 是式中的一个基团： 和 α 是二价基团，包括式中的重复单元： 其中 n 为不小于 1 的数字；a、b、c、d、e 和 f 为相同或不同且为 0-3 的数字，条件是 d + f 不小于 1；R₁、R₂ 和 R₃ 是相同或不同的 C₁-C₁₈ 烷基、C₁-₁₈ 烷氧基、羧基或卤原子；R₄ 是氢原子、C₁-C₁₈ 烷基或芳基，这种抗蚀剂组合物对辐射敏感，并在敏感性、分辨力和耐热性之间具有良好的平衡。
• GB919126
  申请人：——

  公开号：——

  公开（公告）日：——