acetic acid pyridazin-3-yl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: acetic acid pyridazin-3-yl ester
• 英文别名: Essigsaeure-pyridazin-3-ylester；Pyridazin-3-yl acetate
• 化学式: C₆H₆N₂O₂
• 分子量: 138.126
• InChiKey: AAQLCVOBBOXZOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  呋喃 、 乙酸酐 在 硝酸 作用下， 生成 哒嗪 、 acetic acid pyridazin-3-yl ester
  参考文献：
  名称：

  Hueckel; Jahnentz, Chemische Berichte, 1942, vol. 75, p. 1438,1439

  摘要：

  DOI：

文献信息

• NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF
  申请人：Hutchinson John Howard

  公开号：US20150025064A1

  公开（公告）日：2015-01-22

  The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R 1 , R 2 , R 4 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, methods of use of such compounds and compositions, and methods for preparing the compounds and compositions. The compounds are Group II metabotropic glutamate antagonists or allosteric modulators and are useful for the treatment of a variety of CNS disorders.

  本发明涉及式(I)的新型苯二氮平酮化合物，其中R1、R2、R4、R6、R7、R8、R9和R10如本文所定义。本发明还涉及含有这种化合物的制药组合物、使用这种化合物和组合物的方法，以及制备这种化合物和组合物的方法。这些化合物是第二组代谢型谷氨酸拮抗剂或变构调节剂，可用于治疗各种中枢神经系统疾病。
• Process for Producing Olefin Copolymerization Catalyst and Process for Producing Olefin Copolymer
  申请人：NAKAHARA Shinya

  公开号：US20080227937A1

  公开（公告）日：2008-09-18

  A process for producing an olefin copolymerization catalyst, comprising the step of contacting, with one another, (A) a solid catalyst component containing a titanium atom, a magnesium atom and a halogen atom, (B) an organoaluminum compound and/or organoaluminumoxy compound, and (C) a nitrogen-containing aromatic heterocyclic compound, whose one or more carbon atoms adjacent to its nitrogen atom are linked to an electron-donating group, or a group containing an electron-donating group; and a process for producing an olefin copolymer using the an olefin copolymerization catalyst.
• US7605215B2
  申请人：——

  公开号：US7605215B2

  公开（公告）日：2009-10-20
• US9193710B2
  申请人：——

  公开号：US9193710B2

  公开（公告）日：2015-11-24
• [EN] NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF<br/>[FR] NOUVEAUX BENZODIAZÉPINONES EN TANT QUE MODULATEURS DE FONCTIONS D'UN RÉCEPTEUR MÉTABOTROPIQUE DU GLUTAMATE, ET UTILISATIONS NEUROLOGIQUES DE CEUX-CI
  申请人：BRAINCELLS INC

  公开号：WO2013033246A2

  公开（公告）日：2013-03-07

  The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R1, R2, R4, R6, R7, R8, R9, and R10 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, methods of use of such compounds and compositions, and methods for preparing the compounds and compositions. The compounds are Group II metabotropic glutamate antagonists or allosteric modulators and are useful for the treatment of a variety of CNS disorders.